{"title":"与衰老失调相关的盐驱动染色质重塑在癌症亚型胃癌发生中起着至关重要的作用","authors":"Karthik Balakrishnan","doi":"10.1016/j.comtox.2023.100262","DOIUrl":null,"url":null,"abstract":"<div><p>Many studies previously reported that salt (NaCl) at high concentrations has genotoxicity and carcinogenicity features in human cells. The current study used an integrative functional-genomics approach to identify the effect of high salt-driven dysregulation in gastric cancer subtype carcinogenesis. Therefore, gene sets related to salt, chromatin, and senescence were collected from the molecular signatures database and investigated their expression in the many gastric cancer mRNA expression profile cohorts and its cell lines profile using pathway-focused gene-sets activation scoring methods. In this study, high salt-induced chromatin remodeling associated with senescence-mediated dysregulation are exceedingly abundant in the intestinal subtype gastric tumors. This critical finding should pave the path for the targeted therapeutics treatment in the subtype of gastric tumors.</p></div>","PeriodicalId":37651,"journal":{"name":"Computational Toxicology","volume":null,"pages":null},"PeriodicalIF":3.1000,"publicationDate":"2023-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"2","resultStr":"{\"title\":\"Salt-driven chromatin remodeling associated with senescence dysregulation plays a crucial role in the carcinogenesis of gastric cancer subtype\",\"authors\":\"Karthik Balakrishnan\",\"doi\":\"10.1016/j.comtox.2023.100262\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Many studies previously reported that salt (NaCl) at high concentrations has genotoxicity and carcinogenicity features in human cells. The current study used an integrative functional-genomics approach to identify the effect of high salt-driven dysregulation in gastric cancer subtype carcinogenesis. Therefore, gene sets related to salt, chromatin, and senescence were collected from the molecular signatures database and investigated their expression in the many gastric cancer mRNA expression profile cohorts and its cell lines profile using pathway-focused gene-sets activation scoring methods. In this study, high salt-induced chromatin remodeling associated with senescence-mediated dysregulation are exceedingly abundant in the intestinal subtype gastric tumors. This critical finding should pave the path for the targeted therapeutics treatment in the subtype of gastric tumors.</p></div>\",\"PeriodicalId\":37651,\"journal\":{\"name\":\"Computational Toxicology\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":3.1000,\"publicationDate\":\"2023-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"2\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Computational Toxicology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S2468111323000038\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"TOXICOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computational Toxicology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2468111323000038","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"TOXICOLOGY","Score":null,"Total":0}
Salt-driven chromatin remodeling associated with senescence dysregulation plays a crucial role in the carcinogenesis of gastric cancer subtype
Many studies previously reported that salt (NaCl) at high concentrations has genotoxicity and carcinogenicity features in human cells. The current study used an integrative functional-genomics approach to identify the effect of high salt-driven dysregulation in gastric cancer subtype carcinogenesis. Therefore, gene sets related to salt, chromatin, and senescence were collected from the molecular signatures database and investigated their expression in the many gastric cancer mRNA expression profile cohorts and its cell lines profile using pathway-focused gene-sets activation scoring methods. In this study, high salt-induced chromatin remodeling associated with senescence-mediated dysregulation are exceedingly abundant in the intestinal subtype gastric tumors. This critical finding should pave the path for the targeted therapeutics treatment in the subtype of gastric tumors.
期刊介绍：
Computational Toxicology is an international journal publishing computational approaches that assist in the toxicological evaluation of new and existing chemical substances assisting in their safety assessment. -All effects relating to human health and environmental toxicity and fate -Prediction of toxicity, metabolism, fate and physico-chemical properties -The development of models from read-across, (Q)SARs, PBPK, QIVIVE, Multi-Scale Models -Big Data in toxicology: integration, management, analysis -Implementation of models through AOPs, IATA, TTC -Regulatory acceptance of models: evaluation, verification and validation -From metals, to small organic molecules to nanoparticles -Pharmaceuticals, pesticides, foods, cosmetics, fine chemicals -Bringing together the views of industry, regulators, academia, NGOs
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