羧甲基纤维素钠盐对壳聚糖凝胶对食管黏膜保护性能的影响

IF 0.8 Q4 MATERIALS SCIENCE, BIOMATERIALS

Progress on Chemistry and Application of Chitin and its Derivatives Pub Date : 2022-09-30 DOI:10.15259/pcacd.27.014

K. Małolepsza-Jarmołowska

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引用次数: 0

摘要

胃食管反流病是一个严重的社会问题，影响到生活的各个领域。患有这种疾病的人的生活质量由于出现麻烦的症状而降低，这转化为降低工作效率和活力。主要的问题是酸性胃食管反流。本研究旨在探讨水凝胶是否能预防食管黏膜的刺激。目的是研究壳聚糖和羧甲基纤维素钠盐对制备的凝胶治疗胃酸反流防护性能的影响。壳聚糖的加入提高了凝胶的pH值和动态粘度。含0.3%羧甲基纤维素钠盐的凝胶的ph值最高。织构试验表明，羧甲基纤维素钠盐浓度对凝胶的粘附性能有影响。这些凝胶可用于治疗晚期胃酸反流

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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INFLUENCE OF CARBOXYMETHYLCELLULOSE SODIUM SALT ON THE PROTECTIVE PROPERTIES OF GELS WITH CHITOSAN FOR THE OESOPHAGEAL MUCOSA

Gastro-oesophageal reflux disease is a serious social problem that affects every sphere of life. The quality of life of people with this disease is reduced due to the presence of troublesome symptoms, which translates into reduced work efficiency and vitality. The major problem is acidic gastro-oesophageal reflux. This study was undertaken to examine whether hydrogels prevent irritation of the oesophageal mucosa. The aim was to investigate the influence of chitosan and carboxymethylcellulose sodium salt on the protective properties of prepared gels in the treatment of acid reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. Preparations containing 0.3% carboxymethylcellulose sodium salt showed the highest pH. The texture tests showed the effect of carboxymethylcellulose sodium salt concentration on the adhesion work of the tested gels. These gels could be used in the treatment of advanced acid reflux

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来源期刊

Progress on Chemistry and Application of Chitin and its Derivatives MATERIALS SCIENCE, BIOMATERIALS-

CiteScore

1.10

自引率

16.70%

发文量

期刊介绍： Progress in the Chemistry and Application of Chitin and its Derivatives is an annual journal focused on all aspects of production, modification, enzymology and application of chitin and its many derivatives, including chitosan. The journal publishes full-length papers as well as invited reviews. To be considered, papers must present original research that has not been published or accepted for publication elsewhere. The language of the journal will be English.