脑成像告诉我们关于痒的什么?

H. Mochizuki, L. Hernandez, G. Yosipovitch
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引用次数: 8

摘要

了解瘙痒的机制以及慢性瘙痒的病理生理对开发有效的治疗方法至关重要。在过去的25年里,研究人员利用脑功能成像技术研究了健康受试者和慢性瘙痒患者的脑机制。这些研究表明,各种皮层和皮层下区域与瘙痒有关。此外,还发现健康受试者与慢性瘙痒患者在脑活动和脑解剖结构上存在差异。在这篇综述文章中,我们讨论了这些已确定的大脑区域在瘙痒感知中的潜在作用,以及大脑功能和结构变化与慢性瘙痒的关系。还讨论了瘙痒心理调节的脑成像研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
What does brain imaging tell us about itch?
Understanding the mechanism of itch as well as the pathophysiology of chronic itch is important for the development of effective treatments. In the past 25 years, researchers have investigated the cerebral mechanism of itch in healthy subjects and chronic itch patients using functional brain imaging techniques. These studies have demonstrated that a variety of cortical and subcortical areas are associated with itch. In addition, it has been found that there are differences in brain activity and brain anatomy between healthy subjects and chronic itch patients. In this review article, we discuss potential roles of those identified brain regions in itch perception, and associations of the functional and structural changes in the brain with chronic itch. Brain imaging studies of psychological modulations of itch are also discussed.
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