Indicios de fibrogénesis en hígado esteatósico no alcohólico de pacientes con componentes del síndrome metabólico

Non-alcoholic steatosis is generally associated with benign prognosis, however it can progress to fibrosis; the behavior of genes that contribute to their progression to fibrosis are not fully understood yet. The objective of this study was to analize the first signs of fibrogenesis in non-alcoholic steatosis in obese versus non-obese patients. A prospective descriptive study included patients with non-alcoholic steatosis was performed. The patients were divided in two groups, obese and non-obese. Sociodemographic, anthropometric and the suffering of the components of metabolic syndrome information were obtained. Biochemical parameters and expression leves of theTNF-α, NF-kβ, CYP2E1, TGF-β, OPN, COL4α5 and HGF genes were determined by RT-PCR. Our results showed significant differences in the levels of expression of the CYP2E1 gene, the level of expression being higher in obese patients suffering from complete metabolic syndrome. Furthermore, in non-obese patients with steatosis and without components of the metabolic syndrome, TGF-β is activated as a participant in fibrogen pathways and in obese patients with complete metabolic syndrome, the significant expression level of CYP2E1 could indicate an alarm signal Palabras clave: esteatosis hepática no alcohólica; fibrosis; síndrome metabólico; obesidad; expresión génica.