Tasha M. Santiago-Rodriguez , Gino Fornaciari , Stefania Luciani , Gary A. Toranzos , Isolina Marota , Valentina Giuffra , Naseer Sangwan , Raul J. Cano
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Tetracyclines were discovered over 70 years ago and their use resulted in the emergence of tetracycline-resistance microorganisms; however, it has been hypothesized that tetracycline-resistance may have originated in the environment, and that determinants were transferred to the human gut microbiota. Ancient microbiomes represent an opportunity to explore the transmission of tetracycline-resistance determinants from the environment to humans. In the present study, tetracycline-like resistomes of three pre-Inca/Inca (10–15th centuries), and five Italian nobility (15–16th centuries) mummies were characterized using high-throughput sequencing. Sequences exhibited low homology to present-day determinants. Results may aid in the understanding of the evolution of tetracycline-resistance.
期刊介绍：
The innumerable microbes living in and on our bodies are known to affect human wellbeing, but our knowledge of their role is still at the very early stages of understanding. Human Microbiome is a new open access journal dedicated to research on the impact of the microbiome on human health and disease. The journal will publish original research, reviews, comments, human microbe descriptions and genome, and letters. Topics covered will include: the repertoire of human-associated microbes, therapeutic intervention, pathophysiology, experimental models, physiological, geographical, and pathological changes, and technical reports; genomic, metabolomic, transcriptomic, and culturomic approaches are welcome.
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