内脏型和躯体型疼痛反应犬在不同麻醉方案下心率变异性和内源性毒物状态的动态变化

S. Rublenko, A. Yaremchuk
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引用次数: 0

摘要

狗天生具有高损伤水平的特点,高损伤水平可达到总外科病理学的50%。同时,腹部病理学在这类动物中非常常见,分离科的手术治疗伴随着显著的躯体和内脏疼痛反应。这项工作于2015-2020年在比拉·泽尔科娃国立农业大学小宠物外科和疾病科进行。该研究的材料是该大学小动物疾病诊所收治的临床健康和患病的狗。作为研究的临床实验基础,考虑了病理学的发病形式和发生频率,并注意了根据动物种类、疼痛反应的类型和强度以及麻醉的正确性进行外科干预的特点。对2至10岁接受腹部手术的狗的内脏型疼痛反应进行了研究。身体疼痛反应伴随骨折及其外科治疗。纳入对年龄在1至10岁之间的股骨或肱骨骨折的狗的研究。高水平的内毒素血症是犬腹部手术病理的病理化学阶段的特征,血液中丙二醛浓度(14.8±0.55μmol/l)和平均重量分子分别为1.6和正常值的两倍。然而,在平衡的乙酰丙嗪-氯胺酮-丙泊酚麻醉下发现最低水平,在43%的副肌强直(LF/HF<0.85)中,分子量肽没有可能的变化,丙二醛水平仅略微增加1.1倍(p 1.15),这是选择合适麻醉方案的关键标准。关键词:心率变异性,内源性中毒,麻醉,狗,疼痛反应类型,内脏神经支配,躯体神经支配。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Dynamics of heart rate variability and the state of endogenous in toxication under different anesthesia regimens in dogs with visceral and somatic types of pain reaction
Dogs are naturally characterized by a high level ofinjuries, which can reach up to 50 % of the total surgicalpathology. At the same time, abdominal pathology issignificantly common in this species of animals andsurgical treatment of the sepathologies is accompanied bya significant somatic and visceral pain response. The workwas performed at the Department of Surgery and Diseasesof Small Pets of Bila Tserkva National Agrarian Universityin the period 2015-2020. The material for the study wereclinically healthy and sick dogs admitted to the clinic ofdiseases of small animals of the university. Forming theclinical-experimental base for research, nosological formsof pathology and frequency of its occurrence were taken into account, attention was paid to the peculiarities of surgicalintervention depending on the species of animals, type andintensity of pain response and correctness of anesthesia.Visceral type of pain reaction was studied in dogs aged2 to 10 years, who underwent abdominal surgery. Somaticpain reaction accompanies bone fractures and their surgicaltreatment. Included in the study of dogs with fractures of thefemur or humerus aged from 1 to 10 years.High levels of endotoxicosis are characteristic of thepathochemical phase of abdominal surgical pathology in dogs,with the concentration in the blood of malonic dialdehyde(14.8 ± 0.55 μmol / l) and molecules of average weight isrespectively 1.6 and twice higher than normal. However,the lowest level was found under balanced acepromazineketamine-propofol anesthesia, with no probable changes inmolecular weight peptides and a slight increase in the level ofmalonic dialdehyde only 1.1 times (p <0,01).Acepromazine-butorphanol-propofol-ketamineanesthesia for somatic pain in dogs provides completeanalgesia with controlled and rapid recovery fromanesthesia without established probable changes during theoperation of spectral indicators of heart rate variability. Insomatic pain in dogs, regardless of the anesthesia regimen,the preoperative level of endotoxemia is preserved, andaccording to the spectral analysis of HRV and its sympathoparasympathetic balance index, 30 % of surgically ill dogsshow normotonia – 0.85–1.15, 27 – sympathicotonia (LF/HF>1.15), in 43 % – parasimaticotonia (LF/HF<0.85),which is the key criterion for selecting the appropriatescheme of anesthesia. Key words: heart rate variability, endogenousintoxication, anesthesia, dogs, types of pain reaction, visceralinnervation, somatic innervation.
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