海洋大环内酯类药物的潜在应用：来自海洋的新药？

IF 1.4 Q3 MARINE & FRESHWATER BIOLOGY

International Aquatic Research Pub Date : 2020-09-01 DOI:10.22034/IAR(20).2020.1898824.1048

M. Gammone, N. D’Orazio

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引用次数: 1

摘要

海洋是一个未开发和未开发的广阔生态系统，其结果是物种极其丰富：海洋生物是许多化合物和物质的来源，具有许多生物活动。重要的海洋生物活性分子包括大环内酯类，由于其潜在的抗炎、抗菌（不仅是抗菌和抗真菌，还有抗原生动物和抗病毒）、抗氧化、免疫调节和抗肿瘤能力，大环内酯可能成为新的有效药物和疗法的来源。这篇综述的目的是考察这些有趣而迷人的新型海洋生物活性化合物的生物活性以及潜在的临床和药物应用。

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Potential applications of marine macrolides: New drugs from the sea?

The sea is an untapped and unexploited wide ecosystem, which results to be extremely rich in diverse species: marine organisms are a source of many compounds and substances with numerous biological activities. Important marine biologically active molecules are, among others, macrolides, which could become the source of new and effective medicaments and therapeutics, due to their potential anti-inflammatory, antimicrobial (not only antibacterial and antifungal, but also antiprotozoal and antiviral), antioxidant, immunomodulant and antitumor capacities. Aim of this review is to examine the biological activities and the potential clinical and pharmaceutical applications of these interesting and fascinating novel marine bioactive compounds.

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来源期刊

International Aquatic Research MARINE & FRESHWATER BIOLOGY-

CiteScore

2.40

自引率

7.70%

发文量

审稿时长

12 weeks

期刊介绍： The journal (IAR) is an international journal that publishes original research articles, short communications, and review articles in a broad range of areas relevant to all aspects of aquatic sciences (freshwater and marine). The Journal specifically strives to increase the knowledge of most aspects of applied researches in both cultivated and wild aquatic animals in the world. The journal is fully sponsored, which means it is free of charge for authors. The journal operates a single-blind peer review process. The main research areas in aquatic sciences include: -Aquaculture- Ecology- Food science and technology- Molecular biology- Nutrition- Physiology- Water quality- Climate Change