中、低分化肝内胆管癌患者18F-FDG最大标准摄取与病理分化、肿瘤大小和Ki67之间的相关性。

IF 0.9 4区医学 Q4 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Hellenic journal of nuclear medicine Pub Date : 2022-04-08 DOI:10.1967/s002449912435

Yi-qiu Zhang, Bei-lei Li, Yibo He, Lifang Pang, Hao-jun Yu, Hongcheng Shi

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Pathological characteristics of the tumor such as the largest tumor diameter, differentiation, Ki67 expression, SUVmax of the primary tumor, and the tumor to normal background ratio (TNR) were recorded.\n\n\nRESULTS\nAmong the 116 lesions, 45, 51, and 20 lesions were classified into the moderately differentiated, moderately-poorly, and poorly differentiated groups, respectively. There were significant differences in the SUVmax (P=0.033) and TNR (P=0.044) among the three groups. Maximum SUV was significantly correlated with differentiation (r=0.244, P=0.008). When the cases were categorized according to the tumor size (group 1, ≤3cm, n=14; group 2, >3 and ≤5 cm, n=37; group 3, >5 and ≤10 cm, n=52; group 4, >10 cm, n=13), there were significant differences in the SUVmax (P<0.001) and TNR (P<0.001) among the four groups. Maximum SUV was significantly correlated with tumor size (r=0.481, P<0.001). 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引用次数: 1

摘要

目的探讨中、低分化双肝胆管癌(ICC)患者氟-18-氟脱氧葡萄糖(18F-FDG)正电子发射断层扫描/计算机断层扫描(PET/CT)最大标准化摄取值(SUVmax)与肿瘤分化、大小、Ki67的相关性。材料与方法回顾性分析116例经病理证实的单发ICC病变的18F-FDG PET/CT影像资料。记录肿瘤的病理特征，如最大肿瘤直径、分化、Ki67表达、原发肿瘤SUVmax、肿瘤与正常背景比(TNR)等。结果116例病变中，中分化组45例，中分化组51例，低分化组20例。三组间SUVmax (P=0.033)、TNR (P=0.044)差异均有统计学意义。最大SUV与分化显著相关(r=0.244, P=0.008)。按肿瘤大小分组(1组≤3cm, n=14;第2组，bbb3≤5 cm, n=37;第3组，bbb5≤10 cm, n=52;组4，>10 cm, n=13)， 4组间SUVmax (P<0.001)、TNR (P<0.001)差异均有统计学意义。最大SUV与肿瘤大小显著相关(r=0.481, P<0.001)。116个病变中，Ki67低表达组38个，Ki67高表达组78个。两组患者的SUVmax (P=0.028)和TNR (P=0.007)差异有统计学意义。最大SUV与Ki67表达显著相关(r=0.242, P=0.009)。结论在中、低分化ICC中，SUVmax和TNR与肿瘤分化、大小和Ki67表达有显著相关性。

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Correlation among maximum standardized 18F-FDG uptake and pathological differentiation, tumor size, and Ki67 in patients with moderately and poorly differentiated intrahepatic cholangiocarcinoma.

OBJECTIVE To investigate the correlation among the maximum standardized uptake value (SUVmax) on fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) and tumor differentiation, size, and Ki67 in patients with moderately and poorly differentiate dintrahepatic cholangiocarcinoma (ICC). MATERIALS AND METHODS The 18F-FDG PET/CT imaging data of 116 patients with single ICC lesions confirmed by pathology were retrospectively evaluated. Pathological characteristics of the tumor such as the largest tumor diameter, differentiation, Ki67 expression, SUVmax of the primary tumor, and the tumor to normal background ratio (TNR) were recorded. RESULTS Among the 116 lesions, 45, 51, and 20 lesions were classified into the moderately differentiated, moderately-poorly, and poorly differentiated groups, respectively. There were significant differences in the SUVmax (P=0.033) and TNR (P=0.044) among the three groups. Maximum SUV was significantly correlated with differentiation (r=0.244, P=0.008). When the cases were categorized according to the tumor size (group 1, ≤3cm, n=14; group 2, >3 and ≤5 cm, n=37; group 3, >5 and ≤10 cm, n=52; group 4, >10 cm, n=13), there were significant differences in the SUVmax (P<0.001) and TNR (P<0.001) among the four groups. Maximum SUV was significantly correlated with tumor size (r=0.481, P<0.001). Among the 116 lesions, 38 lesions and 78 lesions were classified into the low Ki67 and high Ki67 expression groups, respectively. There were significant differences in the SUVmax (P=0.028) and TNR (P=0.007) between the two groups. Maximum SUV was significantly correlated with Ki67 expression (r=0.242, P=0.009). CONCLUSION In moderately and poorly differentiated ICC, the SUVmax and TNR are significantly associated with tumor differentiation, size, and Ki67 expression.

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来源期刊

Hellenic journal of nuclear medicine 医学-核医学

CiteScore

1.40

自引率

6.70%

发文量

审稿时长

>12 weeks

期刊介绍： The Hellenic Journal of Nuclear Medicine published by the Hellenic Society of Nuclear Medicine in Thessaloniki, aims to contribute to research, to education and cover the scientific and professional interests of physicians, in the field of nuclear medicine and in medicine in general. The journal may publish papers of nuclear medicine and also papers that refer to related subjects as dosimetry, computer science, targeting of gene expression, radioimmunoassay, radiation protection, biology, cell trafficking, related historical brief reviews and other related subjects. Original papers are preferred. The journal may after special agreement publish supplements covering important subjects, dully reviewed and subscripted separately.