乙型肝炎病毒共价闭合环状DNA (cccDNA)的检测与清除研究进展

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-11-30 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.11.011

Yuan Tian

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引用次数: 0

摘要

慢性乙型肝炎(CHB)是一个全球性的公共卫生问题，目前的治疗药物不能完全消除肝细胞核中乙型肝炎病毒(HBV)的共价闭合环状DNA (cccDNA)。cccDNA的存在导致HBV持续感染，这种感染很难完全消除。目前，对cccDNA的研究越来越受到重视。只有全面了解它，我们才能找到更好的治疗HBV感染的方法。本文综述了HBV cccDNA的结构、调控、检测和消除。关键词:乙肝病毒;cccDNA;检测;消除

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Advances in the detection and clearance of hepatitis B virus covalently closed circular DNA (cccDNA)

Chronic hepatitis B (CHB) is a worldwide public health problem and current therapeutic drugs cannot completely eliminate the covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) in the liver cell nucleus. The presence of cccDNA leads to the persistent HBV infection, which is hard to be completely eliminated. At present, the research on cccDNA is getting increasing attention. Only by comprehensively understanding it can we find a better way to cure HBV infection. This article reviewed the structure, regulation, detection and elimination of HBV cccDNA. Key words: HBV; cccDNA; Detection; Elimination

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来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.