Qing-Yi Zhang , Jie Tan , Rong Nie , Yu-Ting Song , Xing-Li Zhou , Zi-Yuan Feng , Kai Huang , Chen-Yu Zou , Qi-Juan Yuan , Long-Mei Zhao , Xiu-Zhen Zhang , Yan-Lin Jiang , Li-Min Liu , Jesse Li-Ling , Hui-Qi Xie
{"title":"复合小肠粘膜下层水凝胶通过免疫调节加速伤口愈合","authors":"Qing-Yi Zhang , Jie Tan , Rong Nie , Yu-Ting Song , Xing-Li Zhou , Zi-Yuan Feng , Kai Huang , Chen-Yu Zou , Qi-Juan Yuan , Long-Mei Zhao , Xiu-Zhen Zhang , Yan-Lin Jiang , Li-Min Liu , Jesse Li-Ling , Hui-Qi Xie","doi":"10.1016/j.compositesb.2023.110550","DOIUrl":null,"url":null,"abstract":"<div><p>Small intestinal submucosa (SIS) hydrogel is a potential candidate for wound dressing since its excellent biocompatibility and bioactivities<span>. However, the intrinsic lack of sufficient immunomodulatory activities has limited its application. Herein, tannic acid (TA) and interleukin-10 (IL-10) were supplemented to the SIS hydrogel to fabricate a novel composite hydrogel to confer an immunomodulatory activity. In addition to the improvement in swelling and anti-degradation properties, the composite SIS hydrogel has attained satisfying free radical scavenging and sustained IL-10 release. Meanwhile, the hydrogel possessed excellent anti-oxidative and immunomodulatory abilities to promote the polarization of M2c macrophages, thereby regulating collagen synthesis and providing a favorable immune environment for angiogenesis and extracellular matrix remodeling. Above results have therefore provided a facile but effective strategy to improve the therapeutic effects of the SIS hydrogel and expand its scope of clinical applications.</span></p></div>","PeriodicalId":10660,"journal":{"name":"Composites Part B: Engineering","volume":null,"pages":null},"PeriodicalIF":12.7000,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"5","resultStr":"{\"title\":\"Acceleration of wound healing by composite small intestinal submucosa hydrogels through immunomodulation\",\"authors\":\"Qing-Yi Zhang , Jie Tan , Rong Nie , Yu-Ting Song , Xing-Li Zhou , Zi-Yuan Feng , Kai Huang , Chen-Yu Zou , Qi-Juan Yuan , Long-Mei Zhao , Xiu-Zhen Zhang , Yan-Lin Jiang , Li-Min Liu , Jesse Li-Ling , Hui-Qi Xie\",\"doi\":\"10.1016/j.compositesb.2023.110550\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Small intestinal submucosa (SIS) hydrogel is a potential candidate for wound dressing since its excellent biocompatibility and bioactivities<span>. However, the intrinsic lack of sufficient immunomodulatory activities has limited its application. Herein, tannic acid (TA) and interleukin-10 (IL-10) were supplemented to the SIS hydrogel to fabricate a novel composite hydrogel to confer an immunomodulatory activity. In addition to the improvement in swelling and anti-degradation properties, the composite SIS hydrogel has attained satisfying free radical scavenging and sustained IL-10 release. Meanwhile, the hydrogel possessed excellent anti-oxidative and immunomodulatory abilities to promote the polarization of M2c macrophages, thereby regulating collagen synthesis and providing a favorable immune environment for angiogenesis and extracellular matrix remodeling. Above results have therefore provided a facile but effective strategy to improve the therapeutic effects of the SIS hydrogel and expand its scope of clinical applications.</span></p></div>\",\"PeriodicalId\":10660,\"journal\":{\"name\":\"Composites Part B: Engineering\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":12.7000,\"publicationDate\":\"2023-04-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"5\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Composites Part B: Engineering\",\"FirstCategoryId\":\"5\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1359836823000537\",\"RegionNum\":1,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENGINEERING, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Composites Part B: Engineering","FirstCategoryId":"5","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1359836823000537","RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, MULTIDISCIPLINARY","Score":null,"Total":0}
Acceleration of wound healing by composite small intestinal submucosa hydrogels through immunomodulation
Small intestinal submucosa (SIS) hydrogel is a potential candidate for wound dressing since its excellent biocompatibility and bioactivities. However, the intrinsic lack of sufficient immunomodulatory activities has limited its application. Herein, tannic acid (TA) and interleukin-10 (IL-10) were supplemented to the SIS hydrogel to fabricate a novel composite hydrogel to confer an immunomodulatory activity. In addition to the improvement in swelling and anti-degradation properties, the composite SIS hydrogel has attained satisfying free radical scavenging and sustained IL-10 release. Meanwhile, the hydrogel possessed excellent anti-oxidative and immunomodulatory abilities to promote the polarization of M2c macrophages, thereby regulating collagen synthesis and providing a favorable immune environment for angiogenesis and extracellular matrix remodeling. Above results have therefore provided a facile but effective strategy to improve the therapeutic effects of the SIS hydrogel and expand its scope of clinical applications.
期刊介绍:
Composites Part B: Engineering is a journal that publishes impactful research of high quality on composite materials. This research is supported by fundamental mechanics and materials science and engineering approaches. The targeted research can cover a wide range of length scales, ranging from nano to micro and meso, and even to the full product and structure level. The journal specifically focuses on engineering applications that involve high performance composites. These applications can range from low volume and high cost to high volume and low cost composite development.
The main goal of the journal is to provide a platform for the prompt publication of original and high quality research. The emphasis is on design, development, modeling, validation, and manufacturing of engineering details and concepts. The journal welcomes both basic research papers and proposals for review articles. Authors are encouraged to address challenges across various application areas. These areas include, but are not limited to, aerospace, automotive, and other surface transportation. The journal also covers energy-related applications, with a focus on renewable energy. Other application areas include infrastructure, off-shore and maritime projects, health care technology, and recreational products.