特发性扩张型心肌病患儿维生素D水平

IF 0.3 Q4 PEDIATRICS
D. Raafat, O. El-Asheer, A. Mahmoud, Manal Darwish, N. Osman
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引用次数: 3

摘要

摘要扩张型心肌病(DCM)是儿科心力衰竭的第三大病因。DCM的确切病因在超过一半的病例中是未知的。维生素D受体存在于心肌、血管内皮和平滑肌中,表明维生素D可能具有重要的心脏保护功能。本研究旨在评估特发性扩张型心肌病儿童的血清维生素D水平,并将血清维生素D含量与左心室尺寸和功能联系起来。这项研究是一项描述性的横断面单中心研究,包括44名被诊断为特发性扩张型心肌病的男女儿童。评估血清维生素D水平,并将其与左心室尺寸和功能相关。研究儿童的平均年龄为6.08岁 ± 4.4年。90.9%的特发性扩张型心肌病儿童维生素D缺乏,平均水平为13.48 ng/mL。扩张型心肌病患儿的维生素D水平与分数缩短和左心室舒张末期直径呈负相关。维生素D水平不仅在特发性扩张型心肌病儿童中显著降低,而且与左心室功能障碍的程度显著相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Vitamin D Status in Children with Idiopathic Dilated Cardiomyopathy
Abstract Dilated cardiomyopathy (DCM) is the third leading cause of heart failure in pediatrics. The exact etiology of DCM is unknown in more than half of the cases. Vitamin D receptors are represented in cardiac muscles, endothelium, and smooth muscles of blood vessels suggesting that vitamin D could have a vital cardioprotective function. This study aimed to assess serum level of vitamin D in children with idiopathic DCM and to correlate the serum level of vitamin D with the left ventricular dimensions and function. This study is a descriptive cross-sectional single-center study, includes 44 children of both sexes, diagnosed as idiopathic DCM. Serum level of vitamin D was assessed and correlated with the left ventricular dimensions and function. Mean age of studied children was 6.08 ± 4.4 years. Vitamin D deficiency was found in 90.9% of children with idiopathic DCM with a mean level 13.48 ng/mL. There was a negative correlation between vitamin D level and fraction shortening and left ventricular end-diastolic diameter in children with DCM. Vitamin D level is not only significantly low in children with idiopathic DCM but it is also significantly correlated with the degree of left ventricular dysfunction.
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来源期刊
CiteScore
0.50
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19
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