自体骨髓基质细胞鞘内细胞治疗脊髓术后神经系统后遗症:附2例报告

Pub Date : 2022-10-26 DOI:10.3390/reports5040043

M. Zurita, C. Bonilla, C. Aguayo, C. Fernández-Mateos, P. Martínez, Silvia De La Calle, Nieves Repollés, Esther Moñivas

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引用次数: 0

摘要

背景目的:脊髓良性病变手术后可能出现永久性神经系统后遗症是众所周知的。它们往往是不可逆转的，除了康复之外没有有效的治疗方法。然而，近年来，使用自体骨髓基质细胞(MSCs)对不完全截瘫患者进行鞘内细胞治疗已显示出对脊髓损伤(SCI)后遗症的益处。方法:我们介绍了两例手术后慢性脊髓后遗症患者，他们接受了NC1药物的细胞治疗(反复鞘内给药MSCs)。结果:在这两种情况下，细胞治疗都明显改善了神经系统后遗症，如步态障碍、肠功能障碍或神经性疼痛的恢复。结论:自体间充质干细胞鞘内细胞治疗脊髓手术后神经系统后遗症提供了新的途径。

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Intrathecal Cell Therapy with Autologous Bone Marrow Stromal Cells as a New Tool for Neurologic Sequels after Spinal Cord Surgery: A Report of Two Cases

Background aims: The possibility of permanent neurological sequels after surgery of benign lesions affecting the spinal cord is well known. Frequently, they are irreversible, with no effective treatment other than rehabilitation. However, in recent years, intrathecal cell therapy with autologous bone marrow stromal cells (MSCs) in patients with incomplete paraplegia has shown benefits for diverse sequels of spinal cord injury (SCI). Methods: We present two patients with chronic spinal cord sequels after a surgery, who underwent cell therapy treatment with NC1 medicament (repeated intrathecal administrations of MSCs). Results: In both cases, cell therapy achieved a clear improvement in neurological sequels, such as recovery of gait disturbances, bowel dysfunction, or neuropathic pain. Conclusion: Intrathecal cell therapy with autologous MSCs offers a new approach for neurological sequels after spinal cord surgery.

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