胶质瘤干细胞耐辐射和辐射敏感蛋白质组学研究进展

中华放射肿瘤学杂志 Pub Date : 2020-02-15 DOI:10.3760/CMA.J.ISSN.1004-4221.2020.02.016

Shanshan Zhang, Yuntian Shen, Q. Fan, Ye Tian, Qiang Huang

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引用次数: 0

摘要

经过包括放疗在内的多学科治疗，多形性胶质母细胞瘤(GBM)患者的中位生存期仍约为1年。胶质母细胞瘤干细胞(GSC)基因组和蛋白质组的异质性是影响预后的根本因素。基于蛋白质组学的关键放射耐药蛋白增敏有望改善GBM患者的预后。本文通过对PubMed等数据库近10年的文献综述，系统讨论了各种常用的蛋白质定量技术、数据处理分析工具以及在GSCs放射耐药和放射致敏中的应用研究进展。关键词:瘤干细胞;辐射敏感性;蛋白质组学

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Research progress on radiation-resistant and radiation-sensitive proteomics in glioma stem cells

After multidisciplinary treatment including radiotherapy, the median survival of patients with glioblastoma multiforme (GBM) remains approximately 1 year. The heterogeneity of the genome and proteome of glioblastoma stem cells (GSC) is the fundamental factor affecting the prognosis. Proteomics-based sensitization of key radioresistance proteins is expected to improve the prognosis of GBM patients. In this article, literature review was conducted from PubMed and other databases in the previous 10 years to systematically discuss the research progress on various commonly used protein quantitative techniques, tools for data processing analysis and the application in radioresistance and radiosensitization of GSCs. Key words: Gioma stem cell; Radiation sensitivity; Proteomics

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来源期刊

中华放射肿瘤学杂志

自引率

0.00%

发文量

6375

期刊介绍： The Chinese Journal of Radiation Oncology is a national academic journal sponsored by the Chinese Medical Association. It was founded in 1992 and the title was written by Chen Minzhang, the former Minister of Health. Its predecessor was the Chinese Journal of Radiation Oncology, which was founded in 1987. The journal is an authoritative journal in the field of radiation oncology in my country. It focuses on clinical tumor radiotherapy, tumor radiation physics, tumor radiation biology, and thermal therapy. Its main readers are middle and senior clinical doctors and scientific researchers. It is now a monthly journal with a large 16-page format and 80 pages of text. For many years, it has adhered to the principle of combining theory with practice and combining improvement with popularization. It now has columns such as monographs, head and neck tumors (monographs), chest tumors (monographs), abdominal tumors (monographs), physics, technology, biology (monographs), reviews, and investigations and research.