6-氨基嘧啶-4-(thi) 1衍生物合成嘧啶[4,5 -b]喹诺酮类化合物

IF 1.9 4区化学 Q2 CHEMISTRY, ORGANIC

Mini-reviews in Organic Chemistry Pub Date : 2022-11-04 DOI:10.2174/1570193x20666221104110606

M. Gouda, A. Abu‐Hashem, T. A. Ameen, M. A. Salem

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引用次数: 0

摘要

喹啉和嘧啶是众所周知的部分，出现在各种天然和合成产品中。此外，喹啉嘧啶激发的杂化物已知具有几种生物学特性。此外，在过去的十年中，已经报道了许多嘧啶并[4，5-b]喹啉酮环系统，特别是与药物化学有关的系统。这篇综述描述了通过6-氨基嘧啶-4-（thi）酮衍生物合成嘧啶并[4，5-b]喹诺酮类（PyQs4,5-b）。PyQs4,5-b的制备通过以下化学反应进行了澄清：Vilsmeier Haack甲酰化反应、类Hantzsch反应和一锅三组分反应。

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Synthesis of pyrimido [4, 5-b] quinolones from 6-Aminopyrimidin-4-(thi)one derivatives

Quinoline and pyrimidine are well-known moieties, which appear in various natural and synthetic products. Furthermore, quinoline-pyrimidine-inspired hybrids are known to have several biological properties. In addition, many pyrimido[4,5-b]quinolinone ring systems, specifically concerning medicinal chemistry, have been reported over the past decade. This review depicts the synthesis of pyrimido[4, 5-b] quinolones (PyQs4,5-b) through 6-aminopyrimidin-4-(thi)one derivatives. The preparation of PyQs4,5-b was clarified through the following chemical reactions: Vilsmeier-Haack formylation, Hantzsch-like reaction, and one-pot three-component reaction.

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来源期刊

Mini-reviews in Organic Chemistry 化学-有机化学

CiteScore

4.50

自引率

4.30%

发文量

116

审稿时长

>12 weeks

期刊介绍： Mini-Reviews in Organic Chemistry is a peer reviewed journal which publishes original reviews on all areas of organic chemistry including organic synthesis, bioorganic and medicinal chemistry, natural product chemistry, molecular recognition, and physical organic chemistry. The emphasis will be on publishing quality papers very rapidly, without any charges. The journal encourages submission of reviews on emerging fields of organic chemistry including: Bioorganic Chemistry Carbohydrate Chemistry Chemical Biology Chemical Process Research Computational Organic Chemistry Development of Synthetic Methodologies Functional Organic Materials Heterocyclic Chemistry Macromolecular Chemistry Natural Products Isolation And Synthesis New Synthetic Methodology Organic Reactions Organocatalysis Organometallic Chemistry Theoretical Organic Chemistry Polymer Chemistry Stereochemistry Structural Investigations Supramolecular Chemistry