骨质疏松的干细胞生物再生治疗:文献综述

Q4 Medicine
Olha Nishkumay, Mike K.S. Chan, Y. Nalapko, N. Grygorieva, O. Nikitin, Ilya Kordubailo
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引用次数: 0

摘要

老龄化是我们文明发展的必然过程。自古以来,科学家们就试图解开衰老之谜。这项研究一直持续到今天。老年人最常见的疾病是肌肉骨骼系统疾病。其中,骨质疏松症在总体发病率和死亡率结构中继续占据第三位。这些统计数据使我们思考在分子水平上寻找疾病的可能原因。本研究的目的是分析骨质疏松症治疗的现代方向的文献数据,包括基于干细胞的生物再生医学。2018年至2022年,使用Medline(PubMed)、Web of Science和Scopus数据库、Google Scholar和Cochrane Central Register of Controlled Trials(Central)的信息分析,使用关键词“骨质疏松症”、生物再生疗法、“干细胞疗法”,对文献数据进行了分析综述。最近的临床前实验研究结果表明,引入新的生物再生技术是有效的。特别是间充质干细胞、外泌体和miRNA的用途。MSC移植治疗骨质疏松症的临床前研究表明,成骨分化增加,骨密度增加。外泌体在骨质疏松症的治疗中也可能发挥多种作用:改善破骨细胞和成骨细胞之间的不平衡,外泌体的结构修饰和递质的药物功能。外泌体对骨再生的促进作用已在动物模型中得到证实。含有活性成分的外泌体可以治疗各种骨骼疾病,包括骨质疏松症和骨质疏松性骨折。基于干细胞治疗的骨病治疗的最新研究结果显示出令人信服的新方法前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Stem cell-based bioregenerative therapy of osteoporosis: literature review
Aging is an inevitable process of our civilization. Since ancient times, scientists have tried to solve the mystery of aging. The research continues to this day. The most common diseases of old age are disorders of the musculoskeletal system. Among them, osteoporosis continues to occupy the third place in the structure of overall morbidity and mortality. Such statistical data make us think about the search for a possible cause of the disease at the molecular level. The purpose of this study was to analyze the literature data on modern directions of osteoporosis treatment, including stem-cells based bioregenerative medicine. An analytical review of literature data was conducted using the information analysis of Medline (PubMed), Web of Science and Scopus databases, Google Scholar and the Cochrane Central Register of Controlled Trials (CENTRAL) from 2018 to 2022 using the keywords “osteoporosis”, bioregenerative therapy”, “stem cell therapy”. Recent results of preclinical experimental studies have shown the effectiveness of the introduction of new bioregenerative technologies. In particular, the use of mesenchymal stem cells, exosomes and miRNAs. Preclinical studies on MSC transplantation in the treatment of osteoporosis indicate an increase in osteogenic differentiation, an increase in BMD. Exosomes also may play multiple roles in the treatment of osteoporosis: improving the disbalance between osteoclasts and osteoblasts, structural modification of exosomes and transmitters’ drug function. The promotion of bone regeneration of exosomes has been shown in animal models. Exosomes with active ingredients can treat a variety of skeletal disorders including osteoporosis and osteoporotic fractures. The results of recent research of the bone disorder treatment based on stem cells therapy have shown convincing prospects for new approaches.
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来源期刊
Cell and Organ Transplantology
Cell and Organ Transplantology Medicine-Transplantation
CiteScore
0.40
自引率
0.00%
发文量
8
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