{"title":"谷胱甘肽修复：对抗骨骼肌干细胞衰老的利剑","authors":"Zeming Wu, Jie Ren, Guang-Hui Liu","doi":"10.1093/lifemeta/load012","DOIUrl":null,"url":null,"abstract":"\n In a recent study published in Cell Metabolism, Thomas A. Rando and colleagues reported a critical role of dysregulated glutathione (GSH) metabolism in driving the aging process of skeletal muscle stem cells (MuSCs), uncovering a novel mechanism underlying the divergent responses of quiescent stem cells to environmental stressors with age, thus providing a potentially accessible target to alleviate age-associated skeletal muscle degeneration.","PeriodicalId":74074,"journal":{"name":"Life metabolism","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Glutathione restoration: a sword to combat skeletal muscle stem cell aging\",\"authors\":\"Zeming Wu, Jie Ren, Guang-Hui Liu\",\"doi\":\"10.1093/lifemeta/load012\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"\\n In a recent study published in Cell Metabolism, Thomas A. Rando and colleagues reported a critical role of dysregulated glutathione (GSH) metabolism in driving the aging process of skeletal muscle stem cells (MuSCs), uncovering a novel mechanism underlying the divergent responses of quiescent stem cells to environmental stressors with age, thus providing a potentially accessible target to alleviate age-associated skeletal muscle degeneration.\",\"PeriodicalId\":74074,\"journal\":{\"name\":\"Life metabolism\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-03-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Life metabolism\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1093/lifemeta/load012\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Life metabolism","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1093/lifemeta/load012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 1
摘要
最近发表在《细胞代谢》杂志上的一项研究中，Thomas a . Rando及其同事报道了谷胱甘肽(GSH)代谢失调在驱动骨骼肌干细胞(MuSCs)衰老过程中的关键作用，揭示了静止干细胞随着年龄增长对环境应激源的不同反应的新机制，从而为缓解年龄相关的骨骼肌变性提供了一个潜在的可达靶点。
Glutathione restoration: a sword to combat skeletal muscle stem cell aging
In a recent study published in Cell Metabolism, Thomas A. Rando and colleagues reported a critical role of dysregulated glutathione (GSH) metabolism in driving the aging process of skeletal muscle stem cells (MuSCs), uncovering a novel mechanism underlying the divergent responses of quiescent stem cells to environmental stressors with age, thus providing a potentially accessible target to alleviate age-associated skeletal muscle degeneration.
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