桥本甲状腺炎患儿的氧化应激标志物、微量元素和内分泌干扰物

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2019-08-20 DOI:10.1080/15376516.2019.1646367

Unzile Sur, P. Erkekoğlu, A. Buluş, N. Andıran, B. Kocer-Gumusel

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引用次数: 28

摘要

摘要在本研究中，我们旨在调查双酚A（BPA）和邻苯二甲酸二（2-乙基己基）酯（DEHP）暴露是否与桥本甲状腺炎（HT）及其生物标志物有任何关联，并确定HT儿童的氧化应激生物标志物和微量元素水平是否有任何变化。我们发现HT组的超氧化物歧化酶和谷胱甘肽过氧化物酶活性低于对照组（分别为24%和46%，p < 0.05）。HT组的锌水平显著低于对照组。此外，作为DEHP的主要代谢产物，邻苯二甲酸单（2-乙基己基）酯（MEHP）的水平在HT组明显高于对照组（p < 尿BPA水平与fT4呈负相关。在患有HT的儿童中，氧化剂/抗氧化剂的平衡发生了变化，这些差异可能与EDC暴露有关，其重要性应通过进一步的研究来阐明。

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Oxidative stress markers, trace elements, and endocrine disrupting chemicals in children with Hashimoto’s thyroiditis

Abstract In this study, we aimed to investigate whether bisphenol A (BPA) and di-(2-ethylhexyl) phthalate (DEHP) exposure have any association with Hashimoto’s thyroiditis (HT) and its biomarkers and to determine whether oxidative stress biomarkers and trace element levels showed any alterations in children with HT. We found that superoxide dismutase and glutathione peroxidase activities are lower in HT group from control (24% and 46%, respectively, p < 0.05). Zinc levels were significantly lower in HT group vs. control. In addition, the levels of mono-(2-ethylhexyl) phthalate (MEHP) which is the primary metabolite for DEHP, were markedly higher in HT group compared to control (p < 0.05). A negative correlation was observed between urinary BPA levels and fT4. In children with HT, oxidant/antioxidant balance is changed and these differences may be related by EDC exposure, the importance of which should be elucidated with further studies.

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来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.