顶复合体寄生物的三维基因组组织和毒力

IF 3.2 Q2 GENETICS & HEREDITY
T. Lenz, K. L. Le Roch
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引用次数: 2

摘要

越来越多的证据支持这样一种观点,即表观遗传学和基因组的整体三维结构在真核生物的基因表达中发挥着重要作用。最近,我们使用Hi-C方法生成并比较了7种不同的顶复门寄生虫的3D基因组,包括几种致病性和致病性较低的疟原虫,以及相关的人类寄生虫小巴贝虫和弓形虫。我们的目标是了解这些传染源的基因组组织、基因表达和致病性之间的可能关系。总之,我们的研究结果表明,大多数疟原虫物种的空间基因组组织受到毒力基因共同定位的限制,这些毒力基因对染色体折叠的影响是独特的,这表明基因组组织和毒力更强的病原体中的基因表达之间存在联系。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Three-Dimensional Genome Organization and Virulence in Apicomplexan Parasites
Mounting evidence supports the idea that epigenetic, and the overall 3-dimensional (3D) architecture of the genome, plays an important role in gene expression for eukaryotic organisms. We recently used Hi-C methodologies to generate and compare the 3D genome of 7 different apicomplexan parasites, including several pathogenic and less pathogenic malaria parasites as well as related human parasites Babesia microti and Toxoplasma gondii. Our goal was to understand the possible relationship between genome organization, gene expression, and pathogenicity of these infectious agents. Collectively, our results demonstrate that spatial genome organization in most Plasmodium species is constrained by the colocalization of virulence genes that are unique in their effect on chromosome folding, indicating a link between genome organization and gene expression in more virulent pathogens.
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来源期刊
Epigenetics Insights
Epigenetics Insights GENETICS & HEREDITY-
CiteScore
5.10
自引率
0.00%
发文量
10
审稿时长
8 weeks
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