肺动脉高压的现代治疗方法及其长远发展方向。

Q3 Pharmacology, Toxicology and Pharmaceutics
Anna V. Zagrebelnaya, L. Korokina, T. Malorodova, Olesya V. Shcheblykina, T. Avtina, Anton A. Bolgov, E. Malyutina, V. Simonov, Vladislav A. Travkin, Artem А. Dmitriev, Amonullo A. Aripov, Dmitry V. Shcheblykin
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引用次数: 0

摘要

前言:本工作的目的是回顾酸碱度发展的主要发病机制,以及现代建立的治疗各种类型酸碱度的方法,并考虑新的,最相关的和有希望的治疗这种病理的可能性。病因、发病机制和流行病学:在现代疾病结构中,肺动脉高压占有重要地位,约占人口的1%。然而,它的五个主要群体都有自己的特点。肺动脉高压的原因可能是内皮细胞凋亡和血管生成过程的多学破坏,从左心到小循环系统的压力增加的被动传递,导致血管重构的慢性缺氧,以及许多其他原因。总的来说,值得注意的是,尽管病因多种多样,但肺动脉高压发展的主要发病环节是内皮功能障碍。治疗和有前景的研究领域:本文讨论了治疗肺动脉高压的主要方法:对患者的一般建议,用于支持非特异性治疗的药物,以及特定的保守和根治性治疗方法。此外,还介绍了肺动脉高压治疗领域的主要现代科学研究方向。这些有前途的方法,如使用干细胞,基因治疗和表观遗传药物被考虑。结论:尽管对肺动脉高压进行了积极的研究,并且有许多不同的药物用于治疗肺动脉高压,但这种病理状况仍然是一个迫切的健康问题。因此,寻找新的治疗应用点和从根本上治疗肺动脉高压的新方法至今仍具有重要意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Pulmonary hypertension: modern methods of treatment and ways of their long-term development.
Introduction: The purpose of this work is to review the main pathogenetic mechanisms of the development of PH, as well as modern established methods of treatment of various types of PH and to consider new, most relevant and promising possibilities of therapy for this pathology. Etiology, pathogenesis and epidemiology: In the modern structure of diseases, pulmonary hypertension plays a significant role, affecting about 1% of the population. However, each of its five main groups has its own characteristics. The causes of pulmonary hypertension can be a polyetiological violation of the processes of endotheliocyte apoptosis and angiogenesis, passive transmission of increased pressure from the left heart to the small circulatory system, chronic hypoxia, leading to vascular remodeling, and many others. In general, it is worth noting that, despite the multiplicity of etiological factors, the main pathogenetic link in the development of pulmonary hypertension is endothelial dysfunction. Treatment and promising areas of research: This article discusses the main established approaches to the treatment of pulmonary hypertension: general recommendations for patients, drugs used as supportive nonspecific therapy, as well as specific conservative and radical methods of treatment. In addition, the main modern directions of scientific research in the field of treatment of pulmonary hypertension are described. Such promising methods as the use of stem cells, gene therapy and epigenetic drugs are considered. Conclusion: Despite active research and many different drugs intended for the treatment of pulmonary hypertension, this pathological condition remains an urgent health problem. Thus, the search for new points of application of therapy and fundamentally new methods of treatment of pulmonary hypertension remains relevant to this day.
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来源期刊
Research Results in Pharmacology
Research Results in Pharmacology Medicine-Pharmacology (medical)
CiteScore
1.50
自引率
0.00%
发文量
32
审稿时长
12 weeks
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