土耳其狂蜂蜜与5-氟尿嘧啶对大鼠结肠癌模型联合作用的评价

IF 0.7 4区农林科学 Q3 VETERINARY SCIENCES

Ankara Universitesi Veteriner Fakultesi Dergisi Pub Date : 2022-08-09 DOI:10.33988/auvfd.1113279

Efe Kurtdede, M. E. Alçığır, A. Alperen, Berk Baran, Oğuz Kaan Karaca, Erman Gülendağ

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引用次数: 0

摘要

在n-甲基-n -亚硝基脲(MNU)诱导的大鼠结肠癌模型中，目的是评估富含灰色毒素的土耳其疯蜂蜜和5-氟尿嘧啶(5-FU)单独和联合使用的退行性作用。研究组分为对照组(CG)、癌症对照组(CCG)、5-氟脲嘧啶组(FUG)、土耳其狂蜂蜜组(HG)、土耳其狂蜂蜜和5-氟脲嘧啶联合组(FU-HG)。CCG组大鼠WBC、淋巴细胞、嗜酸性粒细胞、嗜碱性粒细胞、血清LDH、TOS和总蛋白水平均显著低于CG组大鼠，血清Bcl-2和survivin水平显著高于CG组大鼠。FU-HG组、FUG组、HG组大鼠结肠和小肠中间变性上皮细胞、血管化、癌前病变和炎症浸润的存在程度均较低(p

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Evaluation of the Combined Effects of Turkish Mad Honey and 5-Fluorouracil in Colon Cancer Model in Rats

In N-methyl-N-nitrosourea (MNU)-induced colon cancer modeling in rats, it was aimed to evaluate the regressive effect of grayanotoxin-rich Turkish mad honey and 5-fluorouracil (5-FU), separately and together. Study groups were control group (CG), cancer control group (CCG), 5-Flourouracil group (FUG), Turkish mad honey group (HG), Turkish mad honey and 5-FU combined group (FU-HG). WBC, lymphocyte, eosinophil, basophil, serum LDH, TOS, and total protein values determined in the rats in the CCG were significantly lower than the values determined in the rats in CG, and serum Bcl-2 and survivin levels were significantly higher. The presence of anaplastic epithelial cells, vascularization, precancerous changes, and inflammatory infiltration detected in the colon and small intestine of the rats in FU-HG, FUG, HG were less intense (p

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来源期刊

Ankara Universitesi Veteriner Fakultesi Dergisi 农林科学-兽医学

CiteScore

1.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Ankara Üniversitesi Veteriner Fakültesi Dergisi is one of the journals’ of Ankara University, which is the first well-established university in the Republic of Turkey. Research articles, short communications, case reports, letter to editor and invited review articles are published on all aspects of veterinary medicine and animal science. The journal is published on a quarterly since 1954 and indexing in Science Citation Index-Expanded (SCI-Exp) since April 2007.