驻极体防止细菌生物膜的形成

IF 3.8 Q2 ENGINEERING, ELECTRICAL & ELECTRONIC
Zhipeng Sun, Hongbao Wang, Xin Guo, Jiajie Xu, Hejuan Liang, Jian Jiang, Yuanyuan Liang
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引用次数: 1

摘要

细菌生物膜的形成是细菌耐药的重要因素。抑制细菌生物膜的常用方法是合成药物,如抗菌肽,但物理方法往往安全、无毒、制备简单。本工作提出了一种环保的方法,利用驻极体膜在细菌生物膜形成过程中提供稳定的电场,通过电场的作用抑制细菌生物膜的形成,减弱细菌生物膜的粘附。经驻极体阳性处理后,金黄色葡萄球菌生物膜总量较对照组减少20%。胞外多糖的分布也表明生物膜的活性降低。此外,负驻极体还能抑制细菌生物膜的形成。该结果可推广到其他革兰氏阳性菌,有助于降低细菌耐药性,改善相关抗生素的效果,减少抗生素的用量,减少药物的副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Electret prevents the formation of bacterial biofilm

Electret prevents the formation of bacterial biofilm

Bacterial biofilm formation is an important factor in bacterial resistance. The commonly used methods to inhibit bacterial biofilms are synthetic drugs such as antimicrobial peptides, but physical methods are often safe, non-toxic and simple to prepare. This work proposes an environmentally friendly method to use electret films to provide a stable electric field during the formation of bacterial biofilms, inhibit the formation of bacterial biofilms through the action of the electric field and weaken the adhesion of bacterial biofilms. The total amount of Staphylococcus aureus biofilm decreased by 20% compared to the control group after the treatment of positive electret. The distribution of exopolysaccharides showed that the activity of biofilm also decreased. In addition, the negative electret can also inhibit the formation of bacterial biofilm. The result can be generalised to other Gram-positive bacteria and could contribute to reduce the resistance of bacteria, improve the effect of related antibiotics, reduce the dosage of antibiotics and reduce the side effects of drugs.

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来源期刊
IET Nanodielectrics
IET Nanodielectrics Materials Science-Materials Chemistry
CiteScore
5.60
自引率
3.70%
发文量
7
审稿时长
21 weeks
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