标准偏差:传动比失真的生物学基础。

IF 8.7 1区生物学 Q1 GENETICS & HEREDITY

Annual review of genetics Pub Date : 2019-12-03 DOI:10.1146/annurev-genet-112618-043905

L. Fishman, Mariah McIntosh

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引用次数: 36

摘要

孟德尔遗传的规律是非常稳健的，但在遗传作图群体中也经常观察到在一个基因座上偏离替代等位基因的平等传递[也称为传递比畸变（TRD）]。这样的TRD揭示了在二倍体杂合子亲本和后代基因分型之间的某个点上起作用的位点特异性选择，因此可以为其他隐藏的遗传和进化过程提供新的见解。大多数经典的自私遗传元素都是通过它们的传播偏差发现的，但许多无私的进化和发育过程也会产生TRD。在这篇综述中，我们描述了在图谱群体中检测TRD的方法，详细介绍了在植物和动物繁殖过程中形成TRD的领域和遗传相互作用，并总结了遗传图谱文献中TRD的模式。最后，我们指出了新的实验方法，可以加速TRD的检测和潜在遗传机制的表征。《遗传学年度评论》第53卷预计最终在线出版日期为2019年11月23日。请参阅http://www.annualreviews.org/page/journal/pubdates用于修订估算。

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Standard Deviations: The Biological Bases of Transmission Ratio Distortion.

The rule of Mendelian inheritance is remarkably robust, but deviations from the equal transmission of alternative alleles at a locus [a.k.a. transmission ratio distortion (TRD)] are also commonly observed in genetic mapping populations. Such TRD reveals locus-specific selection acting at some point between the diploid heterozygous parents and progeny genotyping and therefore can provide novel insight into otherwise-hidden genetic and evolutionary processes. Most of the classic selfish genetic elements were discovered through their biasing of transmission, but many unselfish evolutionary and developmental processes can also generate TRD. In this review, we describe methodologies for detecting TRD in mapping populations, detail the arenas and genetic interactions that shape TRD during plant and animal reproduction, and summarize patterns of TRD from across the genetic mapping literature. Finally, we point to new experimental approaches that can accelerate both detection of TRD and characterization of the underlying genetic mechanisms. Expected final online publication date for the Annual Review of Genetics, Volume 53 is November 23, 2019. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.

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来源期刊

Annual review of genetics 生物-遗传学

CiteScore

18.30

自引率

0.90%

发文量

期刊介绍： The Annual Review of Genetics, published since 1967, comprehensively covers significant advancements in genetics. It encompasses various areas such as biochemical, behavioral, cell, and developmental genetics, evolutionary and population genetics, chromosome structure and transmission, gene function and expression, mutation and repair, genomics, immunogenetics, and other topics related to the genetics of viruses, bacteria, fungi, plants, animals, and humans.