{"title":"当失去有效控制时管理新技术:面对Crispr的艰难选择","authors":"Joel Andrew Zimbelman","doi":"10.1111/jore.12406","DOIUrl":null,"url":null,"abstract":"<div>\n \n <p>This paper seeks to expand our appreciation of the gene editing tool, clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9), its function, its benefits and risks, and the challenges of regulating its use. I frame CRISPR's emergence and its current use in the context of 150 years of formal exploration of heredity and genetics. I describe CRISPR's structure and explain how it functions as a useful engineering tool. The contemporary international and domestic regulatory environment governing human genetic interventions is reviewed and shown to be increasingly ineffective in its ability to restrain, guide, and optimize the emerging use of CRISPR. Several reasons for this lack of consensus are discussed. In conclusion, I suggest a number of public policy recommendations that might allow us to simultaneously embrace our most important moral values and manage the inevitable power CRISPR will come to have in our lives.</p>\n </div>","PeriodicalId":45722,"journal":{"name":"JOURNAL OF RELIGIOUS ETHICS","volume":null,"pages":null},"PeriodicalIF":0.5000,"publicationDate":"2022-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"1","resultStr":"{\"title\":\"Managing New Technology When Effective Control is Lost: Facing Hard Choices With CRISPR\",\"authors\":\"Joel Andrew Zimbelman\",\"doi\":\"10.1111/jore.12406\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n <p>This paper seeks to expand our appreciation of the gene editing tool, clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9), its function, its benefits and risks, and the challenges of regulating its use. I frame CRISPR's emergence and its current use in the context of 150 years of formal exploration of heredity and genetics. I describe CRISPR's structure and explain how it functions as a useful engineering tool. The contemporary international and domestic regulatory environment governing human genetic interventions is reviewed and shown to be increasingly ineffective in its ability to restrain, guide, and optimize the emerging use of CRISPR. Several reasons for this lack of consensus are discussed. In conclusion, I suggest a number of public policy recommendations that might allow us to simultaneously embrace our most important moral values and manage the inevitable power CRISPR will come to have in our lives.</p>\\n </div>\",\"PeriodicalId\":45722,\"journal\":{\"name\":\"JOURNAL OF RELIGIOUS ETHICS\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.5000,\"publicationDate\":\"2022-11-05\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"1\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"JOURNAL OF RELIGIOUS ETHICS\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/jore.12406\",\"RegionNum\":3,\"RegionCategory\":\"哲学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"0\",\"JCRName\":\"RELIGION\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"JOURNAL OF RELIGIOUS ETHICS","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/jore.12406","RegionNum":3,"RegionCategory":"哲学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"0","JCRName":"RELIGION","Score":null,"Total":0}
Managing New Technology When Effective Control is Lost: Facing Hard Choices With CRISPR
This paper seeks to expand our appreciation of the gene editing tool, clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9), its function, its benefits and risks, and the challenges of regulating its use. I frame CRISPR's emergence and its current use in the context of 150 years of formal exploration of heredity and genetics. I describe CRISPR's structure and explain how it functions as a useful engineering tool. The contemporary international and domestic regulatory environment governing human genetic interventions is reviewed and shown to be increasingly ineffective in its ability to restrain, guide, and optimize the emerging use of CRISPR. Several reasons for this lack of consensus are discussed. In conclusion, I suggest a number of public policy recommendations that might allow us to simultaneously embrace our most important moral values and manage the inevitable power CRISPR will come to have in our lives.
期刊介绍:
Founded in 1973, the Journal of Religious Ethics is committed to publishing the very best scholarship in religious ethics, to fostering new work in neglected areas, and to stimulating exchange on significant issues. Emphasizing comparative religious ethics, foundational conceptual and methodological issues in religious ethics, and historical studies of influential figures and texts, each issue contains independent essays, commissioned articles, and a book review essay, as well as a Letters, Notes, and Comments section. Published primarily for scholars working in ethics, religious studies, history of religions, and theology, the journal is also of interest to scholars working in related fields such as philosophy, history, social and political theory, and literary studies.