最大剂量为30 mg的阿立哌唑与奥氮平联合用药

Q4 Medicine

Psychiatria Pub Date : 2020-05-30 DOI:10.5603/psych.2020.0013

Paweł Mierzejewski

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引用次数: 0

摘要

阿立哌唑是一种具有独特药理特性的抗精神病药物，对D2受体具有ago-拮抗作用，被归类为第三代抗精神病药物。临床和临床前研究表明，在选定的患者中，高剂量阿立哌唑的有效性和安全性，支持最大剂量为30毫克/天的用药决定。本文介绍了大剂量阿立哌唑的作用机理，并讨论了最大剂量用药的临床情况。研究的第二部分提出了阿立哌唑与奥氮平和其他II代抗精神病药物联合使用的有益效果的论点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Arypiprazol w dawce maksymalnej 30 mg i w połączeniu z olanzapiną

Aripiprazole is an antipsychotic drug with unique pharmacological properties showing ago-antagonistic effects against the D2 receptor and is classified as a III generation antipsychotic. Clinical and preclinical studies indicate efficacy and safety of high doses of aripiprazole in selected patients, supporting the decision to use the drug at a maximum dose of 30 mg/day. This paper presents the mechanism of action of high doses of aripiprazole and discusses clinical situations when it is appropriate to use the drug at the maximum dose. The second part of the study presents arguments for beneficial effects of the combination of aripiprazole with olanzapine and other antipsychotic drugs of II generation.

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来源期刊

Psychiatria Medicine-Psychiatry and Mental Health

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： "Psychiatry" is a quaternary journal addressed to professionals coming from all branches of psychiatry practicing in both hospital and outpatients departments. "Psychiatry" issues original articles, reviews, case reports, commentaries, and translated articles from leading journals in the field of psychiatry. The papers are reviewed by the members of the editorial board. "Psychiatry" also publishes the practice guidelines in sexology. Psychopharmacotherapy is the main field of interests of the quatrernary.