微波化学:利用微波辐射合成嘌呤和嘧啶核苷

IF 1.2 4区化学 Q4 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Carbohydrate Chemistry Pub Date : 2019-01-01 DOI:10.1080/07328303.2018.1543430

Galal H. Elgemeie , Reham A. Mohamed

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引用次数: 7

摘要

摘要嘧啶和嘌呤核苷对药物化学和制药工业有着显著而全面的影响。它们成为日益增长的抗代谢跨学科领域的关键部分。核苷类似物的极端重要性引发了其在治疗关键疾病如癌症、恶性肿瘤、微生物感染和自身免疫性疾病中的广泛应用。综述了近年来微波辅助有机合成（MAOS）技术的进展。

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Microwave chemistry: Synthesis of purine and pyrimidine nucleosides using microwave radiation

Pyrimidine and purine nucleosides have a remarkable and comprehensive impact on medicinal chemistry and pharmaceutical industries. They become key parts of the growing interdisciplinary area of antimetabolites. The paramount importance of the nucleoside analogs triggered their broader use in treatment of critical diseases such as cancer, malignancies, microbial infection, and autoimmune diseases. Recent advances in their synthetic strategies through microwave-assisted organic synthesis (MAOS) have been reviewed.

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来源期刊

Journal of Carbohydrate Chemistry 化学-生化与分子生物学

CiteScore

2.10

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： The Journal of Carbohydrate Chemistry serves as an international forum for research advances involving the chemistry and biology of carbohydrates. The following aspects are considered to fall within the scope of this journal: -novel synthetic methods involving carbohydrates, oligosaccharides, and glycoconjugates- the use of chemical methods to address aspects of glycobiology- spectroscopic and crystallographic structure studies of carbohydrates- computational and molecular modeling studies- physicochemical studies involving carbohydrates and the chemistry and biochemistry of carbohydrate polymers.