Jenske J.M. Vermeulen , Anne-Jet S. Jansen , Sam van de Sande , Yvonne A.W. Hartman , Suzanne Holewijn , Michel M.P.J. Reijnen , Dick H.J. Thijssen
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Observer-independent software was used to analyze and calculate magnitude and timing of maximum vasodilation or vasoconstriction. Pearson's correlation coefficient was calculated to investigate vasoreactivity between arteries.</p></div><div><h3>Results</h3><p>Carotid artery reactivity [Interquartile range 25%, Interquartile range 75%] did not significantly differ between the young, matched and AAA group (3.5% [1.4, 4.7], 2.6% [2.0, 4.1] and 2.2% [-1.9, 3.7], respectively, p = 0.301). Abdominal aortic responsiveness demonstrated larger differences between young (4.9% [-0.2, 8.4]), matched (3.3% [-2.5, 4.4]) and individuals with AAA (0.5% [-3.9, 4.1], p = 0.059). Pooled analysis showed a significant correlation between carotid and abdominal aortic vasoreactivity (r = 0.444, p = 0.001). Subgroup analyses demonstrated significant correlation between both arteries in young (r = 0.636, p = 0.003), but not matched (r = −0.040, p = 0.866) or AAA group (r = 0.410, p = 0.129).</p></div><div><h3>Conclusions</h3><p>Sympathetic stimulation induces powerful vasodilation of the carotid artery and abdominal aorta, which is significantly correlated in healthy individuals. No such correlation is present in abdominal aortic aneurysm patients. 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引用次数: 0
摘要
背景:对中心动脉(如冠状动脉和颈动脉)的交感刺激在健康受试者中引起血管扩张，但在心血管风险增加的受试者中引起血管收缩。本研究比较了健康年轻人(年轻组，n = 20)、腹主动脉瘤患者(AAA组，n = 20)和年龄和性别与AAA组匹配的健康老年人(匹配组，n = 18)对腹主动脉和颈动脉交感刺激的血管反应性。方法所有受试者均行冷压试验，同时行腹主动脉和颈动脉血管反应性超声检查。使用独立于观察者的软件分析和计算最大血管舒张或血管收缩的幅度和时间。计算Pearson相关系数来研究动脉间的血管反应性。结果青年组、匹配组和AAA组颈动脉反应性[四分位范围25%，四分位范围75%]差异无统计学意义(分别为3.5%[1.4,4.7]、2.6%[2.0,4.1]和2.2% [-1.9,3.7]，p = 0.301)。腹主动脉反应性在年轻人(4.9%[-0.2,8.4])、匹配者(3.3%[-2.5,4.4])和AAA患者(0.5% [-3.9,4.1]，p = 0.059)之间差异较大。合并分析显示颈动脉与腹主动脉血管反应性有显著相关性(r = 0.444, p = 0.001)。亚组分析显示，年轻组两种动脉有显著相关性(r = 0.636, p = 0.003)，但AAA组(r = 0.410, p = 0.129)不匹配(r = - 0.040, p = 0.866)。结论交感神经刺激可引起颈动脉和腹主动脉强烈的血管舒张，二者之间存在显著相关性。在腹主动脉瘤患者中没有这种相关性。这表明动脉瘤改变了局部腹主动脉的血管反应性，但没有改变颈动脉。
Carotid artery vasoreactivity correlates with abdominal aortic vasoreactivity in young healthy individuals but not in patients with abdominal aortic aneurysm
Background
Sympathetic stimulation of central arteries, such as coronary and carotid arteries, cause vasodilation in healthy subjects, but vasoconstriction in those with increased cardiovascular risk. This study compared vasoreactivity to sympathetic stimulation between abdominal aorta and carotid artery in healthy young individuals (young group, n = 20), in patients with abdominal aortic aneurysm (AAA group, n = 20) and in a healthy older group, age- and gender matched with AAA group (matched group, n = 18).
Method
All subjects underwent cold pressor test, while performing concomitantly duplex ultrasound of abdominal aorta and carotid artery vasoreactivity. Observer-independent software was used to analyze and calculate magnitude and timing of maximum vasodilation or vasoconstriction. Pearson's correlation coefficient was calculated to investigate vasoreactivity between arteries.
Results
Carotid artery reactivity [Interquartile range 25%, Interquartile range 75%] did not significantly differ between the young, matched and AAA group (3.5% [1.4, 4.7], 2.6% [2.0, 4.1] and 2.2% [-1.9, 3.7], respectively, p = 0.301). Abdominal aortic responsiveness demonstrated larger differences between young (4.9% [-0.2, 8.4]), matched (3.3% [-2.5, 4.4]) and individuals with AAA (0.5% [-3.9, 4.1], p = 0.059). Pooled analysis showed a significant correlation between carotid and abdominal aortic vasoreactivity (r = 0.444, p = 0.001). Subgroup analyses demonstrated significant correlation between both arteries in young (r = 0.636, p = 0.003), but not matched (r = −0.040, p = 0.866) or AAA group (r = 0.410, p = 0.129).
Conclusions
Sympathetic stimulation induces powerful vasodilation of the carotid artery and abdominal aorta, which is significantly correlated in healthy individuals. No such correlation is present in abdominal aortic aneurysm patients. This suggests the aneurysm alters local abdominal aorta vasoreactivity, but not the carotid artery.
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