外生殖器子宫内膜异位症患者肠道微生物群变化及其与IL6、IL8和TNFα水平的关系

IF 0.2 Q4 MEDICINE, GENERAL & INTERNAL
L. Gumenyuk, IA Zemlyanaya, A. Rami, ES Badula, AR Ismailov, NA Seroshtanov, SS Kokareva, AA Cheremisova, YuR Kupreichyuk
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引用次数: 0

摘要

今天,肠道微生物群与外生殖器子宫内膜异位症(EGE)的关联具有特殊的科学意义。该研究旨在评估肠道微生物群分类组成的变化,并在物种水平上探讨它们与血浆il - 6、il - 8和tnf - α水平的相关性。横断面比较研究纳入50例EGE患者(指数组)和50例健康女性(对照组)。评估肠道微生物群分类组成和血浆中il - 6、il - 8和tnf - α水平的变化。大肠杆菌患者肠道菌群分类组成中,牛粪球菌(Coprococcus catu)、血Turicibacter sanguinis (Turicibacter sanguinis)、瘤胃球菌(Ruminococcus gnavus)的丰度显著降低,而分枝真杆菌(Eubacterium ramulus)、多雷杆菌(Bacterioides dorei)、divia普雷沃菌(Prevotella divia)、福氏志杆菌(Shigella flexneri)的丰度显著升高。il - 6水平与血Turicibacter sanguinis丰度显著相关(r = -0.92;il - 8水平和福氏志贺氏菌丰度(r = 0.72;p < 0.001)、tnf - α水平和divia普氏菌丰度(r = 0.77;(r = 0.001)。这一发现增加了关于肠道微生物群改变特征及其与EGE个体炎症生物标志物关联的现有文献数据,可以证明在该领域的进一步研究是合理的,并可能开辟治疗该疾病的新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Gut microbiota alterations and their association with IL6, IL8 and TNFα levels in patients with external genital endometriosis
Today, the association of gut microbiota with external genital endometriosis (EGE) is of special scientific interest. The study was aimed to assess alterations of the gut microbiota taxonomic composition and explore their correlations with plasma levels of IL6, IL8 and TNFα at the species level in patients with EGE. The crosssectional comparative study involved 50 patients with EGE (index group) and 50 healthy women (control group). The changes in the gut microbiota taxonomic composition and plasma levels of IL6, IL8 and TNFα were assessed. A significant decrease in the abundance of such species, as Coprococcus catu (р = 0.009), Turicibacter sanguinis (р = 0.008) and Ruminococcus gnavus (р < 0.001), along with the increase in the abundance of Eubacterium ramulus (р = 0.040), Bacterioides dorei (р = 0.001), Prevotella divia (р = 0.008) and Shigella flexneri (р < 0.001) were found in the gut microbiota taxonomic composition in patients with EGE. Significant correlations between the IL6 levels and the abundance of Turicibacter sanguinis (r = –0.92; р = 0.001), IL8 levels and the abundance of Shigella flexneri (r = 0.72; р < 0.001), TNFα levels and the abundance of Prevotella divia (r = 0.77; р = 0.001) were revealed. The findings add to the available literature data on the features of gut microbiota alterations and their association with some inflammation biomarkers in individuals with EGE, which can justify further research in this area and probably open up new approaches to treatment of the disease.
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来源期刊
Bulletin of Russian State Medical University
Bulletin of Russian State Medical University MEDICINE, GENERAL & INTERNAL-
CiteScore
0.80
自引率
0.00%
发文量
59
期刊介绍: Bulletin of Russian State Medical University (Bulletin of RSMU, ISSN Print 2500–1094, ISSN Online 2542–1204) is a peer-reviewed medical journal of Pirogov Russian National Research Medical University (Moscow, Russia). The original language of the journal is Russian (Vestnik Rossiyskogo Gosudarstvennogo Meditsinskogo Universiteta, Vestnik RGMU, ISSN Print 2070–7320, ISSN Online 2070–7339). Founded in 1994, it is issued once every two months publishing articles on clinical medicine and medical and biological sciences, first of all oncology, neurobiology, allergy and immunology, medical genetics, medical microbiology and infectious diseases. Every issue is thematic. Deadlines for manuscript submission are announced in advance. The number of publications on topics in spite of the issue topic is limited. The journal accepts only original articles submitted by their authors, including articles that present methods and techniques, clinical cases and opinions. Authors must guarantee that their work has not been previously published elsewhere in whole or in part and in other languages and is not under consideration by another scientific journal. The journal publishes only one review per issue; the review is ordered by the editors.
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