放射治疗中光子中子绝对剂量评估的被动方法

Q4 Health Professions
K. R. Rajesh, R. Raman, M. Musthafa, C. V. Midhun, N. Joseph
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引用次数: 3

摘要

背景:在放射治疗过程中,当高能X射线与直线加速器头部结构相互作用时,会产生光子中子。目前的TPS没有考虑到光中子剂量和与之相关的生物效应。老年癌症患者的晚期肿瘤诱导和疾病复发是经常被报道的。材料与方法:采用西门子Primus Plus直线加速器15 MV X射线放射治疗的患者为研究对象。本文用cr39ssntd测量了直线加速器头的光子中子谱,并用Geant4计算了相应的剂量。在人体等效组织模型中,采用kerma评价方法计算了直线加速器头部的复合光子中子谱和相应剂量。核数据的重复计算结果和协方差误差分析结果具有一致性和2%的精度。结果:高能X射线在放射治疗过程中沉积了大量的光子中子剂量。患者自身产生的光子中子是另一个主要问题,它将导致场外剂量。结论:本研究对放射治疗规划和防护中考虑光子中子剂量具有重要意义。这个额外的剂量可能是诱发癌症的一个因素,也可能是先前治愈的患者癌症复发的一个因素。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A passive method for absolute dose evaluation of photoneutrons in radiotherapy
Background: Photoneutrons are produced during the radiotherapy treatment, when high energy X rays interacts with structures of the head of the linear accelerator (linac). The present day TPS are not taking into account the photo-neutron dose and the biological effects associated with it. The late induction of cancer and recurrence of the disease in old cancer patients are being frequently reported. Materials and Methods: Patients undergoing radiotherapy treatment with 15 MV X rays from a Siemens Primus Plus linear accelerator was considered for the study. In the present work, photoneutron spectrum from the linac head is measured using CR 39 SSNTD and the corresponding dose is calculated using Geant4. The composite photoneutron spectrum from the linac head and the corresponding dose was calculated using the kerma evaluation method in a human equivalent tissue phantom. The repeated calculation outcomes and the covariance error analysis in the nuclear data give consistency and an accuracy of 2 % in the results. Results: The result shows that significant amount of photoneutron dose was deposited during radiotherapy treatment when high energy X rays are used. The photoneutron production from the patient itself is yet another major issue which will cause out off field dose. Conclusion: This work gives importance in considering the photoneutron dose during radiotherapy planning and protection. This extra dose might be a factor that contributes to the induction of cancer and also to the recurrence of cancer to previously cured patients.
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来源期刊
Iranian Journal of Radiation Research
Iranian Journal of Radiation Research RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-
CiteScore
0.67
自引率
0.00%
发文量
0
审稿时长
>12 weeks
期刊介绍: Iranian Journal of Radiation Research (IJRR) publishes original scientific research and clinical investigations related to radiation oncology, radiation biology, and Medical and health physics. The clinical studies submitted for publication include experimental studies of combined modality treatment, especially chemoradiotherapy approaches, and relevant innovations in hyperthermia, brachytherapy, high LET irradiation, nuclear medicine, dosimetry, tumor imaging, radiation treatment planning, radiosensitizers, and radioprotectors. All manuscripts must pass stringent peer-review and only papers that are rated of high scientific quality are accepted.
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