阿片类药物在癌症疼痛中的逐渐减少:一项前瞻性研究

IF 0.9 Q3 ANESTHESIOLOGY

Journal of Pain & Palliative Care Pharmacotherapy Pub Date : 2023-07-03 DOI:10.1080/15360288.2023.2234260

Brooke Lochridge, Taylor W. Butler, T. Reese, Karen A. Hande, A. Cass, Lindsay Mundy, Lauren Poe

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引用次数: 0

摘要

背景:慢性疼痛在癌症患者中很常见且使人衰弱。疼痛患病率在癌症幸存者中为39.3%，在癌症治疗期间为55%，在晚期、转移性或终末期疾病中为66.4%。患有癌症或有癌症病史的患者，可能会有与癌症或其治疗有关的疼痛。与阿片类药物相关的耐受性和依赖性已经建立。国家综合癌症网络(NCCN)成人癌症疼痛指南包括基于非癌症疼痛证据的阿片类药物逐渐减少的考虑。在癌症患者和癌症幸存者中，阿片类药物的逐渐减少可能是合理的，以优化患者的安全、疼痛和功能。由于有更好的证据表明低剂量阿片类药物治疗和停药的益处，本研究的目的是在癌症患者中成功实施和评估阿片类药物减量。

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Opioid Tapering in Cancer Pain: A Prospective Study

Background: Chronic pain is common and debilitating in cancer patients. The pain prevalence rate is 39.3% in cancer survivors, 55% during cancer treatment, and 66.4% in advanced, metastatic, or terminal disease. Patients with cancer, or a history of cancer, may have pain related to cancer or its treatments. Tolerance and dependence associated with opioids are established. The National Comprehensive Cancer Network (NCCN) Adult Cancer Pain guideline includes considerations for opioid tapering based on evidence from non-cancer pain. Opioid tapering may be warranted among cancer patients and cancer survivors to optimize patient safety, pain, and functionality. With better evidence to show the benefits of low-dose opioid therapy and discontinuation, the purpose of this study was to successfully implement and evaluate opioid tapering among cancer patients.

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来源期刊

Journal of Pain & Palliative Care Pharmacotherapy ANESTHESIOLOGY-

CiteScore

1.60

自引率

9.10%

发文量