新型双硫化物加合物2-（（4,5-二苯基-4H-1,2,4-三唑-3-基）硫代乙醛的合成

IF 0.6 Q4 CHEMISTRY, ORGANIC

Molbank Pub Date : 2023-08-24 DOI:10.3390/m1715

B. Pintea, I. Burcă, V. Badea, F. Péter

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引用次数: 0

摘要

目前的工作范围是合成S-烷基化的1,2,4-三唑-3-硫醇衍生物。合成分两步进行：在第一步中，使用卤化缩醛和碳酸铯对4,5-二苯基-4H-1,2,4-三唑-3-硫醇进行S-烷基化。在第二步中，测试了几种缩醛脱保护程序，并将获得的醛分离为亚硫酸氢盐加合物。用FT-IR、1D和2DNMR等方法对新化合物的结构进行了表征。

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Synthesis of a Novel 2-((4,5-Diphenyl-4H-1,2,4-triazol-3-yl)thio)acetaldehyde as a Bisulfite Adduct

The scope of the current work was to synthesize an S-alkylated 1,2,4-triazole-3-thiol derivative. Synthesis was carried out in two steps: in the first step, 4,5-diphenyl-4H-1,2,4-triazole-3-thiol was S-alkylated using a halogenated acetal and cesium carbonate. In the second step, several acetal deprotection procedures were tested, and the aldehyde obtained was isolated as a bisulfite adduct. The structures of the new compounds were characterized by FT-IR, 1D, and 2D NMR spectroscopic methods.

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来源期刊

Molbank Chemistry-Physical and Theoretical Chemistry

CiteScore

0.70

自引率

33.30%

发文量

174

审稿时长

11 weeks

期刊介绍： •organic synthesis •biosynthesis •extraction and purification •natural product derivatives •structural elucidation (X-ray crystallography, NMR, etc.)