产科患者评估:新冠肺炎大流行期间的妊娠结局——罗马尼亚单中心回顾性研究

Pub Date : 2022-07-11 DOI:10.3390/reports5030027
M. Mitranovici, D. Chiorean, Ioan Emilian Oală, I. Petre, O. Cotoi
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引用次数: 1

摘要

与急性呼吸综合征相关的冠状病毒2型或严重急性呼吸系统综合征冠状病毒2型已成为我国的一个公共卫生问题。它主要影响弱势人群,尤其是那些有合并症的人群。在这项回顾性研究中,我们开始探索新冠肺炎对妊娠的影响,孕妇感染SARS-CoV-2的脆弱性也是主要关注点。我们包括39名严重急性呼吸系统综合征冠状病毒2型检测呈阳性的患者和39名从罗马尼亚Hunedoara县急诊医院招募的对照受试者。我们的目的是探索新冠肺炎大流行对妊娠的间接影响,因为我们的患者群体被纳入“高风险”类别。结果,剖宫产占了上风,主要原因是胎儿缺氧。新生儿通过出生后实时聚合酶链式反应(RT-PCR)病毒检测进行评估:没有发现严重急性呼吸系统综合征冠状病毒2型感染,也没有检测到病毒的垂直传播。此外,我们没有观察到新冠肺炎导致孕产妇或新生儿死亡。严重急性呼吸系统综合征冠状病毒2型已被发现会导致多器官损伤的异质性表现,其进化尚不清楚。在我们的研究中,抗病毒治疗的需求是有限的,但抗凝剂被证明在改善结果方面是有效的。
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Evaluation of the Obstetric Patient: Pregnancy Outcomes during COVID-19 Pandemic—A Single-Center Retrospective Study in Romania
Acute respiratory-syndrome-related coronavirus 2, or SARS-CoV-2, has become a public health issue in our country. It mainly affects the vulnerable population, especially those with comorbidities. In this retrospective study, we set out to explore the effects of COVID-19 on pregnancy, with the vulnerability of pregnant women to SARS-CoV-2 infection also representing a main focus. We included 39 patients who tested positive for SARS-CoV-2 and 39 control subjects recruited from the Emergency County Hospital of Hunedoara, Romania. Our aim was to explore the indirect impact of the COVID-19 pandemic on pregnancy, as our patient group was included in the “high-risk” category. As a result, cesarean section prevailed, the main reason being fetal hypoxia. Newborns were evaluated by real-time postnatal polymerase chain reaction (RT-PCR) viral testing: none exhibited SARS-CoV-2 infection, with no vertical transmission of the virus being detected. Moreover, we observed no maternal or neonatal deaths resulting from COVID-19. SARS-CoV-2 has been found to cause a heterogeneity of manifestations with damage to multiple organs, and its evolution remains unknown. In our study, the need for antiviral treatment was limited, but anticoagulants proved effective in terms of improving the outcome.
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