Ameliorative Effect of Mushroom Extracts against Butyl Paraben Induced Toxicity in Liver and Kidney in Female Albino Rats.

Ameliorative Effect of Extracts Induced Toxicity in in Rats. Abstract Parabens are group of preservatives chemical compounds used in cosmetics, personal hygiene product, food products and pharmaceuticals . In this study the hepatorenal toxicity due to exposure to paraben was evaluated. In this study design Twenty-four of albino rats experimentally used. Butyle paraben (BP) orally was given to animals 180 days in dose of 4.6 mg\kg.bw which equal to10 % of the LD50 of BP. The extract of Mushroom was given by stomach tube in dose of 10 mg/kg/day for six 180 days. Exposure to Parabens exhibited histopathological and biochemical alterations. In the line of biochemical analysis BP induced toxic changes in both liver and kidney, the hepatic cellular enzymes concentrations (AST, ALT), Bilirubin, urea and creatinine were raised. In contrast plasma proteins were decreased in comparison to the control group. In renal and hepatic tissues BP administration induced vascular congestion as well as necrosis in the hepatorenal epithelium. Both the biochemical and histopathological alteration was improved after giving mushroom extracts in comparison to BP given group. In conclusion, mushroom extracts exhibited biochemical and histopathological improvement in liver and kidney against the toxicity by Butylparaben.