前列腺癌的“超扫描”扫描版本

S. Mironov, V. Sergienko
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引用次数: 0

摘要

一种罕见的“超扫描”闪烁扫描现象被认为是一种所有骨骼部位异常高的促骨放射性药物扩散积聚,同时缺乏肾脏和组织背景成像。这一特征反映了转移性、代谢性或血液学性质的全身性骨系统病变。我们对一例癌症前列腺癌患者在控制雄激素剥夺治疗过程中获得的闪烁扫描数据进行了临床观察和回顾性评估。基于对“超扫描”体征的分析,包括颅骨对99mТс-焦磷酸盐的过度固定,以及伴随的前列腺特异性抗原和甲状旁腺激素(PTH)水平,认为所确定的闪烁扫描现象具有代谢性质,其发生可能是由于PTH和甲状旁腺激素相关蛋白的异位产生,在前列腺癌症发生中起着众所周知的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
“Superscan” Scintigraphic Version for Prostate Cancer
A rare scintigraphic phenomenon of “superscan” is considered – an abnormally high diffuse accumulation of osteotropic radiopharmaceutical by all skeletal parts in combination with the absence of kidney and tissue background imaging. This feature reflects a generalized bone system lesion of metastatic, metabolic or hematological nature. We present a clinical observation and retrospective assessment of scintigraphic data obtained during controlling androgen deprivation therapy in a patient with prostate cancer. Based on the analysis of “superscan” signs, including 99mТс-pyrophosphate hyperfixation by skull bones, as well as concomitant levels of prostatic specific antigen and parathyroid hormone (PTH), it was suggested that the identified scintigraphic phenomenon had metabolic nature, and its occurrence was possibly due to ectopic production of both PTH and parathyroid hormone-related protein, playing a well-known role in prostate cancer genesis.
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