从大型海藻紫菜中提取的硫酸半乳糖聚糖可恢复STZ诱导的糖尿病大鼠抗氧化代谢酶

海岸生命医学杂志(英文版) Pub Date : 2017-02-01 DOI:10.12980/JCLM.5.2017J6-278

R. Lavanya, Fasina Makkar, M. Anusree, K. Chakraborty, L. Valluru

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引用次数: 3

摘要

通过DPPH、ABTS、羟基自由基和一氧化氮自由基活性测定FM4的体外抗氧化能力。对FM4进行了纯化，并用1H-NMR和FTIR对其进行了表征。单剂量STZ (55 mg/kg体重)腹腔注射诱导糖尿病。糖尿病大鼠分别口服FM4(80、100、125 mg/kg BW) 60 d。测定酶促和非酶促抗氧化剂如超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GPx)、过氧化氢酶(CAT)、谷胱甘肽s -转移酶(GST)、脂质过氧化物酶(LPx)、谷胱甘肽还原性(GSH)、维生素c (vitc)和维生素e (vite)水平。格列本脲作为标准药物。

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Sulphated galactopyran derived from Gracilaria opuntia, a marine macroalgae restores the antioxidant metabolic enzymes during STZ induced diabetic rats

In vitro antioxidant assays of FM4 were estimated by DPPH, ABTS, hydroxyl free radical and Nitric oxide free radical activities. FM4 was purified and characterized by 1H-NMR spectra and FTIR as sulphated galactopyran. Diabetes was induced intraperitonially by single dose of STZ (55 mg/kg body weight). FM4 was administrated orally (80, 100, 125 mg/kg BW) to diabetic rats for 60 days. The enzymatic and non-enzymatic antioxidants such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), glutathione-S-transferase (GST), lipid peroxidase (LPx), glutathione reduced (GSH), vitamin-C (VIT-C) and vitamin-E (VIT-E) levels were estimated. Glibenclamide was used as standard drug.

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海岸生命医学杂志(英文版)

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