Caldesmon在转移性和非转移性口腔鳞状细胞癌中的表达:上皮间质转化的介质

Q3 Dentistry

Journal of Orofacial Sciences Pub Date : 2019-07-01 DOI:10.4103/jofs.jofs_140_19

B. Sekar, R. Saranyan, R. Nirmal, Indrapriyadharshini Kumaresan, A. Murugesan, L. Kamaraj

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引用次数: 0

摘要

在过去的几十年里，口腔鳞状细胞癌(OSCC)患者的长期生存率保持不变，这为研究提供了广阔的平台。Caldesmon (CaD)是一种肌动蛋白-肌球蛋白结合蛋白，在细胞骨架调节和细胞运动中起重要作用。本研究的目的是评估CaD在转移性和非转移性OSCC中的表达，并讨论CaD在上皮间质转化中的可能作用。材料和方法:包括25例转移性和25例非转移性OSCC患者的档案块，免疫组织化学方法评估CaD表达。结果:不同级别转移性和非转移性OSCC中CaD的总体表达和染色强度均有统计学意义。总之，在鳞状细胞癌分级的增加中观察到CaD的高表达，但肿瘤的转移潜力似乎与CaD没有任何关系。

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Caldesmon Expression in Metastatic and Non-Metastatic Oral Squamous Cell Carcinoma—A Mediator of Epithelial Mesenchymal Transition

Introduction: For the past decades long-term survival of oral squamous cell carcinoma (OSCC) patients remain unchanged which provides a wide platform for research. Caldesmon (CaD), an actin-myosin binding protein, has a contributing role in cytoskeleton modulation and cell motility. The aim of this study is to evaluate the expression of CaD in metastatic and non-metastatic OSCC and to discuss the possible role of CaD in epithelial mesenchymal transition. Materials and Methods: Archival blocks of 25 metastatic and 25 non-metastatic OSCC patients are included where CaD expression is evaluated immunohistochemically. Results: Overall expression and staining intensity of CaD were statistically significant in different grades of metastatic and non-metastatic OSCC. In summary, high expression of CaD is observed in increasing grades of OSCC but the metastatic potential of the tumour doesn’t seem to have any relation with CaD.

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来源期刊

Journal of Orofacial Sciences Dentistry-Orthodontics

CiteScore

0.60

自引率

0.00%

发文量

审稿时长

31 weeks

期刊介绍： Journal of Orofacial Sciences is dedicated to noblest profession of Dentistry, and to the young & blossoming intellects of dentistry, with whom the future of dentistry will be cherished better. The prime aim of this journal is to advance the science and art of dentistry. This journal is an educational tool to encourage and share the acquired knowledge with our peers. It also to improves the standards and quality of therauptic methods. This journal assures you to gain knowledge in recent advances and research activities. The journal publishes original scientific papers with special emphasis on research, unusual case reports, editorial, review articles, book reviews & other relevant information in context of high professional standards.