太赫兹光谱作为研究生物分子水合壳的一种方法

IF 4.9 Q1 BIOPHYSICS
Biophysical reviews Pub Date : 2023-09-07 eCollection Date: 2023-10-01 DOI:10.1007/s12551-023-01131-z
Nikita V Penkov
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引用次数: 0

摘要

生物分子的水合作用是构成生物的基本过程之一。大多数生物分子的天然构象的形成只有在水环境中才有可能。同时,不仅水影响生物分子的结构,生物分子也会影响水的结构,形成水合壳。然而,对生物分子结构的研究远远超过对其水合壳的研究。随着太赫兹光谱方法的发展,水合作用研究取得了真正的突破,这表明生物分子的水合作用外壳不仅限于1-2层强结合水,还包括更遥远的水合作用区域,并改变了分子动力学。这篇综述研究了太赫兹频率范围的基本特征,作为水在水化过程中变化的结构和动态特性的信息来源。介绍了太赫兹光谱在生物分子水合壳研究中的应用方法。总结了太赫兹光谱学应用至今所获得的各种主要类型生物分子水合作用的数据。重点放在扩展水合壳可能参与实现生物分子的生物学功能,同时对其结构和动力学特性的认识不足。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Terahertz spectroscopy as a method for investigation of hydration shells of biomolecules.

The hydration of biomolecules is one of the fundamental processes underlying the construction of living matter. The formation of the native conformation of most biomolecules is possible only in an aqueous environment. At the same time, not only water affects the structure of biomolecules, but also biomolecules affect the structure of water, forming hydration shells. However, the study of the structure of biomolecules is given much more attention than their hydration shells. A real breakthrough in the study of hydration occurred with the development of the THz spectroscopy method, which showed that the hydration shell of biomolecules is not limited to 1-2 layers of strongly bound water, but also includes more distant areas of hydration with altered molecular dynamics. This review examines the fundamental features of the THz frequency range as a source of information about the structural and dynamic characteristics of water that change during hydration. The applied approaches to the study of hydration shells of biomolecules based on THz spectroscopy are described. The data on the hydration of biomolecules of all main types obtained from the beginning of the application of THz spectroscopy to the present are summarized. The emphasis is placed on the possible participation of extended hydration shells in the realization of the biological functions of biomolecules and at the same time on the insufficient knowledge of their structural and dynamic characteristics.

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来源期刊
Biophysical reviews
Biophysical reviews Biochemistry, Genetics and Molecular Biology-Biophysics
CiteScore
8.90
自引率
0.00%
发文量
93
期刊介绍: Biophysical Reviews aims to publish critical and timely reviews from key figures in the field of biophysics. The bulk of the reviews that are currently published are from invited authors, but the journal is also open for non-solicited reviews. Interested authors are encouraged to discuss the possibility of contributing a review with the Editor-in-Chief prior to submission. Through publishing reviews on biophysics, the editors of the journal hope to illustrate the great power and potential of physical techniques in the biological sciences, they aim to stimulate the discussion and promote further research and would like to educate and enthuse basic researcher scientists and students of biophysics. Biophysical Reviews covers the entire field of biophysics, generally defined as the science of describing and defining biological phenomenon using the concepts and the techniques of physics. This includes but is not limited by such areas as: - Bioinformatics - Biophysical methods and instrumentation - Medical biophysics - Biosystems - Cell biophysics and organization - Macromolecules: dynamics, structures and interactions - Single molecule biophysics - Membrane biophysics, channels and transportation
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