凤凰花精油的毒性研究Wistar大鼠种子

O. Oluyele, M. Oladunmoye, Ayodele Oluwayemisi Ogundare
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引用次数: 3

摘要

本研究评价了凤凰籽精油(PDEO)在Wistar大鼠体内的口服毒性作用。PDEO是通过蒸汽蒸馏技术提取的。急性毒性研究评估了在一组(n=5)大鼠中单剂量施用该油,然后进行24小时观察。对于亚急性毒性评估,将动物随机分为五组(n=3)。第1-4组大鼠分别接受62.5、125、250和500 mg/kg bw的PDEO 14天,而第五组作为对照。研究结束时,采集血样进行生化和血液学分析,同时对重要器官进行组织病理学检查。这项研究的结果显示,动物没有死亡或异常行为变化。在各治疗组中观察到体重和血液学参数的剂量相关增加(p<0.05)。在500 mg/kg bw的剂量下,PDEO导致试验大鼠的生化标志物水平轻微升高,肝脏和肾脏的组织学结构发生轻微变化。这项研究表明,在浓度低于500毫克/千克体重时,PDEO表现出显著的造血特性,对实验大鼠的重要器官没有不良影响。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Toxicity Studies on Essential Oil from Phoenix dactylifera (L.) Seed in Wistar Rats
This study evaluated the toxicological effect of oral administration of Phoenix dactylifera seed essential oil (PDEO) in Wistar rats. PDEO was extracted through a steam-distillation technique. Acute toxicity study evaluated administration of a single dose of the oil in a group (n = 5) of rats followed by 24 h observation, for sub-acute toxicity evaluation, the animals were randomly divided into five groups (n = 3). Group 1 to 4 rats, respectively, received 62.5, 125, 250, and 500 mg/kg bw of PDEO for fourteen days, while the fifth group served as control. At the termination of the study, blood samples were obtained for biochemical and hematological analyses, while vital organs were histopathologically examined. Results from this study revealed no mortality or abnormal behavioral changes in the animals. A dose-related increase in bodyweight and hematological parameters was observed across the treated groups (p < 0.05). At a dosage of 500 mg/kg bw, PDEO caused slight elevation in biochemical marker levels and mild changes in histological architecture of liver and kidney of the test rats. This study revealed that PDEO exhibited significant hematopoietic attributes with no adverse effect on the experimental rats’ vital organs at concentrations below 500 mg/kg bw.
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