评估KEMI方法，以确定保护水生受体免受地表水中化学混合物影响所需的混合物大小评估因子

IF 6.1 Q1 TOXICOLOGY

Current Opinion in Toxicology Pub Date : 2023-08-23 DOI:10.1016/j.cotox.2023.100426

Paul S. Price , Marion Junghans

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引用次数: 0

摘要

本文讨论了瑞典化学品管理局关于估计水生化学品混合物混合物评估因子(KEMI MAF)大小的建议。KEMI MAF是对早期方法的改进，但它依赖于一些不确定的因素，例如:到达水生受体的化学物质的数量、化学物质在评估组中的分配以及未来法规对水中化学物质浓度的影响。本文表明，这些不确定性对水生受体所需maf的大小有显著影响。作为评估的一部分，开发了计算KEMI MAF的简化方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Assessing the KEMI approach for determining the size of mixture assessment factors needed to protect aquatic receptors from chemical mixtures in surface waters

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Assessing the KEMI approach for determining the size of mixture assessment factors needed to protect aquatic receptors from chemical mixtures in surface waters

This article discusses the Swedish Chemicals Agency's proposal for estimating the size of a Mixture Assessment Factor (the KEMI MAF) for aquatic mixtures of chemicals. The KEMI MAF is an improvement over earlier approaches but is dependent on factors that are uncertain, such as: the number of chemicals that reach an aquatic receptor, the allocation of chemicals into assessment groups, and the impacts of future regulations on chemical concentrations in water. This article demonstrates that these uncertainties have significant impacts on the size of MAFs required for aquatic receptors. As part of this assessment a simplified method of calculating the KEMI MAF was developed.

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来源期刊

Current Opinion in Toxicology Pharmacology, Toxicology and Pharmaceutics-Toxicology

CiteScore

10.40

自引率

0.00%

发文量

期刊介绍： The aims and scope of Current Opinion in Toxicology is to systematically provide the reader with timely and provocative views and opinions of the highest qualified and recognized experts on current advances in selected topics within the field of toxicology. The goal is that Current Opinion in Toxicology will be an invaluable source of information and perspective for researchers, teachers, managers and administrators, policy makers and students. Division of the subject into sections: For this purpose, the scope of Toxicology is divided into six selected high impact themed sections, each of which is reviewed once a year: Mechanistic Toxicology, Metabolic Toxicology, Risk assessment in Toxicology, Genomic Toxicology, Systems Toxicology, Translational Toxicology.