补充维生素E可调节自然衰老大鼠体内omega-3脂肪酸的生物学效应

IF 2.8 4区医学 Q2 TOXICOLOGY

Toxicology Mechanisms and Methods Pub Date : 2017-01-08 DOI:10.1080/15376516.2016.1273431

A. Narayanankutty, Anagha Kottekkat, S. E. Mathew, S. P. Illam, I. Suseela, A. Raghavamenon

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引用次数: 22

摘要

Omega-3脂肪酸是众所周知的一类具有健康益处的营养保健品。近年来，这些脂肪酸的氧化产物越来越受到人们的关注，因为它们可能会破坏人体的氧化还原平衡。因此，omega-3脂肪在抗氧化能力下降的情况下的功效，比如衰老，一直是一个值得关注的问题。本研究评估了omega-3脂肪(DHA和EPA)加或不加维生素e对自然衰老大鼠的影响。研究发现，单独摄入omega-3脂肪的大鼠血脂状况得到改善，而omega-3脂肪与维生素e摄入组(OMVE)的大鼠肝保护和抗氧化性能明显，尤其是脑组织的氧化还原状态。维生素e可能减少了omega-3脂肪的过氧化作用，从而使它们具有协同作用。因此，使用维生素e和omega-3脂肪可能对老年人有益。

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Vitamin E supplementation modulates the biological effects of omega-3 fatty acids in naturally aged rats

Abstract Omega-3 fatty acids are well-known class of nutraceuticals with established health benefits. Recently, the oxidation products of these fatty acids are gaining attention, as they are likely to disturb body redox balance. Therefore, the efficacy of omega-3 fats under conditions of diminished antioxidant status, such as aging, is always a concern. Present study assessed the effects of omega-3 fats (DHA and EPA) together with or without vitamin-E in naturally aged rats. It was found that in omega-3 fats alone consumed rats the lipid profile was improved, while in omega-3 fat with vitamin-E-consumed group (OMVE), the hepato protective and antioxidant properties were pronounced, especially the redox status of brain tissue. It is possible that vitamin-E might have reduced the peroxidation of omega-3 fats, thereby allowing their synergistic effects. Hence, the use of vitamin-E along with omega-3 fat may be beneficial under aged conditions.

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来源期刊

Toxicology Mechanisms and Methods TOXICOLOGY-

自引率

3.10%

发文量

期刊介绍： Toxicology Mechanisms and Methods is a peer-reviewed journal whose aim is twofold. Firstly, the journal contains original research on subjects dealing with the mechanisms by which foreign chemicals cause toxic tissue injury. Chemical substances of interest include industrial compounds, environmental pollutants, hazardous wastes, drugs, pesticides, and chemical warfare agents. The scope of the journal spans from molecular and cellular mechanisms of action to the consideration of mechanistic evidence in establishing regulatory policy. Secondly, the journal addresses aspects of the development, validation, and application of new and existing laboratory methods, techniques, and equipment. A variety of research methods are discussed, including: In vivo studies with standard and alternative species In vitro studies and alternative methodologies Molecular, biochemical, and cellular techniques Pharmacokinetics and pharmacodynamics Mathematical modeling and computer programs Forensic analyses Risk assessment Data collection and analysis.