局部用药青光眼患者眼表疾病的患病率

Q4 Medicine

Asian Journal of Ophthalmology Pub Date : 2018-11-21 DOI:10.35119/asjoo.v16i2.382

V. Pai, S. Reddy

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引用次数: 2

摘要

目的:比较使用抗青光眼药物的患者与正常人眼表疾病(OSD)的患病率。设计:前瞻性观察研究。方法:将94例外用药物治疗的青光眼患者纳入研究组。年龄和性别匹配的正常受试者(n = 94)构成对照组。采用眼表疾病指数(OSDI)问卷、泪液破裂时间(TBUT)、丽丝胺绿染色和Schirmer试验对患者进行OSD评估。结果:使用OSDI问卷，研究组的OSD患病率(72.4%)明显高于对照组(44.6%)。Schirmer的测试显示，研究组中84%的患者泪液分泌减少，而对照组为53%。研究组67.1% TBUT异常，对照组47.8% TBUT异常。实验组患者丽丝胺绿染色阳性率为36.2%，对照组为31.8%。结论:与对照组相比，使用降眼压药物的患者更容易出现OSD。长期治疗和多种药物治疗与严重的OSD相关。

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Prevalence of ocular surface disease in patients with glaucoma on topical medications

Aim: To compare the prevalence of ocular surface disease (OSD) in patients using antiglaucoma medications vs normal subjects. Design: Prospective observational study. Methods: A total of 94 patients with glaucoma on topical medications were included in the study group. Age- and gender-matched normal subjects (n = 94) formed the control group. They were assessed for OSD using ocular surface disease index (OSDI) questionnaire, tear break-up time (TBUT), Lissamine green staining, and Schirmer’s test. Results: The prevalence of OSD was significantly more in the study group (72.4%) when compared to controls (44.6%) using the OSDI questionnaire. Schirmer’s test showed 84% patients had decreased tear production in the study group vs 53% in controls. TBUT was abnormal in 67.1% of the study group and of 47.8% controls. Lissamine green staining was positive in 36.2% of patients in the study group and 31.8% of controls. Conclusion: OSD was more common in patients using intraocular pressure (IOP)-lowering drugs than in controls. Long-term therapy and multiple medications were associated with severe OSD.

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来源期刊

Asian Journal of Ophthalmology Medicine-Ophthalmology

自引率

0.00%

发文量

期刊介绍： Asian Journal of OPHTHALMOLOGY is the official peer-reviewed journal of the South East Asia Glaucoma Interest Group (SEAGIG) and is indexed in EMBASE/Excerpta Medica. Asian Journal of OPHTHALMOLOGY is published quarterly (four [4] issues per year) by Scientific Communications International Limited. The journal is published on-line only and is distributed free of cost via the SEAGIG website.