Assessment of Association of ITLN1 SNPs rs2274907A>T and rs2274908 G>A with Coronary Artery Disease in People from Punjab

The objectives of the present study were to determine the genotype and allele frequency distributions of rs2274907 and rs2274908 SNPs of the ITLN1 gene in CAD cases (n=206) and controls (n=206) inhabiting the state of Punjab in northwest India and to seek association, if any, of these SNPs with CAD. Age, lifestyle patterns, dietary habits and various biochemical traits (CHOL, TG, HDL, LDL and VLDL) were examined for possible association with the studied SNP genotypes in CAD cases. Statistically significant differences were found between CAD cases and controls in physical activity (OR=0.27, p<0.0001), alcohol intake (OR=0.67, p=0.04), smoking (OR=1.93, p=0.001), diet type (OR=1.76, p=0.011) and fruit intake (OR=2.62, p<0.0001). All biochemical trait differences were also found to be highly statistically significant (p<0.0001). The present case-control study revealed that both the SNPs at ITLN1 locus were statistically significantly associated with the occurrence of CAD in the people of Punjab.