Jianping Cai, Xiang-feng Zhou, Haibo Yu, Lian-cai Wang, Deyu Li
{"title":"肠内营养对胰十二指肠切除术后急性炎症、免疫细胞和脂质代谢的影响","authors":"Jianping Cai, Xiang-feng Zhou, Haibo Yu, Lian-cai Wang, Deyu Li","doi":"10.3760/CMA.J.ISSN.1007-631X.2020.01.010","DOIUrl":null,"url":null,"abstract":"Objective \nTo study the effects of different parenteral nutrition on acute inflammatory response, immune cells and lipid metabolism in patients after pancreaticoduodenectomy. \n \n \nMethods \nEighty patients after pancreaticoduodenectomy were divided into study group and control group, with 40 cases in each group. Structural fat emulsion was used in study group and medium/long chain fat emulsion in control group. The changes of acute inflammation, immune cells and lipid metabolism were compared between the two groups. \n \n \nResults \n(1)The levels of C-reactive protein (CRP) and serum prostaglandin E2 (PGE2) in the two groups were significantly higher on the first day after operation than those before operation. The difference between the two groups was statistically significant (P<0.05). The level of CRP and PGE2 decreased to the preoperative level on the seventh day after operation, but the decline rate in the study group was significantly faster than that in the control group (P<0.05). (2)The levels of CD3+ , CD4+ , CD8+ , CD4+ /CD8+ in the study group were significantly higher than those in the control group (P<0.05). (3)After 3-7 days of intravenous parenteral nutrition infusion, the blood lipid level was significantly lower in study group (P<0.05). \n \n \nConclusion \nStructural fat emulsion alleviates the inflammatory reaction in patients after pancreaticoduodenectomy, promotes the recovery of immunity, significantly reduces the level of blood lipids. \n \n \nKey words: \nPancreaticoduodenectomy; Parenteral nutrition; C-reactive protein","PeriodicalId":66425,"journal":{"name":"中华普通外科杂志","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2020-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of enteral nutrition on acute inflammation, immune cells and lipid metabolism in patients after pancreaticoduodenectomy\",\"authors\":\"Jianping Cai, Xiang-feng Zhou, Haibo Yu, Lian-cai Wang, Deyu Li\",\"doi\":\"10.3760/CMA.J.ISSN.1007-631X.2020.01.010\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Objective \\nTo study the effects of different parenteral nutrition on acute inflammatory response, immune cells and lipid metabolism in patients after pancreaticoduodenectomy. \\n \\n \\nMethods \\nEighty patients after pancreaticoduodenectomy were divided into study group and control group, with 40 cases in each group. Structural fat emulsion was used in study group and medium/long chain fat emulsion in control group. The changes of acute inflammation, immune cells and lipid metabolism were compared between the two groups. \\n \\n \\nResults \\n(1)The levels of C-reactive protein (CRP) and serum prostaglandin E2 (PGE2) in the two groups were significantly higher on the first day after operation than those before operation. The difference between the two groups was statistically significant (P<0.05). The level of CRP and PGE2 decreased to the preoperative level on the seventh day after operation, but the decline rate in the study group was significantly faster than that in the control group (P<0.05). (2)The levels of CD3+ , CD4+ , CD8+ , CD4+ /CD8+ in the study group were significantly higher than those in the control group (P<0.05). (3)After 3-7 days of intravenous parenteral nutrition infusion, the blood lipid level was significantly lower in study group (P<0.05). \\n \\n \\nConclusion \\nStructural fat emulsion alleviates the inflammatory reaction in patients after pancreaticoduodenectomy, promotes the recovery of immunity, significantly reduces the level of blood lipids. \\n \\n \\nKey words: \\nPancreaticoduodenectomy; Parenteral nutrition; C-reactive protein\",\"PeriodicalId\":66425,\"journal\":{\"name\":\"中华普通外科杂志\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2020-01-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"中华普通外科杂志\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2020.01.010\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华普通外科杂志","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1007-631X.2020.01.010","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Effects of enteral nutrition on acute inflammation, immune cells and lipid metabolism in patients after pancreaticoduodenectomy
Objective
To study the effects of different parenteral nutrition on acute inflammatory response, immune cells and lipid metabolism in patients after pancreaticoduodenectomy.
Methods
Eighty patients after pancreaticoduodenectomy were divided into study group and control group, with 40 cases in each group. Structural fat emulsion was used in study group and medium/long chain fat emulsion in control group. The changes of acute inflammation, immune cells and lipid metabolism were compared between the two groups.
Results
(1)The levels of C-reactive protein (CRP) and serum prostaglandin E2 (PGE2) in the two groups were significantly higher on the first day after operation than those before operation. The difference between the two groups was statistically significant (P<0.05). The level of CRP and PGE2 decreased to the preoperative level on the seventh day after operation, but the decline rate in the study group was significantly faster than that in the control group (P<0.05). (2)The levels of CD3+ , CD4+ , CD8+ , CD4+ /CD8+ in the study group were significantly higher than those in the control group (P<0.05). (3)After 3-7 days of intravenous parenteral nutrition infusion, the blood lipid level was significantly lower in study group (P<0.05).
Conclusion
Structural fat emulsion alleviates the inflammatory reaction in patients after pancreaticoduodenectomy, promotes the recovery of immunity, significantly reduces the level of blood lipids.
Key words:
Pancreaticoduodenectomy; Parenteral nutrition; C-reactive protein