Anacardic Acid通过抑制核因子Kappa B途径减轻心肌细胞缺氧/再充氧损伤

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-07-07 DOI:10.37290/ctnr2641-452x.21:208-214

Yao Liu, Qi-De Song, Ye Tian

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引用次数: 0

摘要

Anacardic acid是一种天然活性成分，具有多种生物和药理学活性，例如作为一种抗氧化剂和心脏保护剂，可抑制组蛋白乙酰化。本研究旨在评价抗坏血酸对心肌缺血再灌注损伤的影响。我们的研究结果显示，在H/R处理的H9C2细胞中，细胞凋亡和氧化应激受到显著抑制。我们的研究结果进一步表明，抗坏血酸的心脏保护作用依赖于对NF-κB通路的抑制。所有这些数据加在一起表明，抗坏血酸是急性心肌梗死的潜在治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Anacardic Acid Alleviates Hypoxia/ReoxygenationInduced Injury in Cardiomyocytes via Suppressing Nuclear Factor-Kappa B Pathway

Anacardic acid is a natural active ingredient that possesses diverse biological and pharmacological activities, such as being an antioxidant and cardioprotective agent that inhibits histone acetylation. This study aimed to evaluate the effect of anacardic acid on myocardial ischemia-reperfusion injury. The results of our studies show a significant inhibition of apoptosis and oxidative stress in H/R-treated H9C2 cells. Our results further reveal that the cardioprotective effect of anacardic acid was dependent on the inhibition of the NF-κB pathway. All these data taken together show anacardic acid as a potential therapeutic target in acute myocardial infarction.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.