恶性胸腔积液姑息性手术治疗的回顾性分析

G. Krajnakova, A. Dzian, M. Skaličanová, Ľ. Hamada, M. Malík, M. Grendár
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引用次数: 0

摘要

摘要简介:恶性胸腔积液(MPE)的形成是晚期恶性肿瘤或其扩散的临床表现。治疗的重点主要是缓解症状,尤其是呼吸困难。材料和方法:回顾性分析2015-2019年在JFMED CU和马丁大学医院胸外科诊所住院的患者的临床数据,并根据他们的医疗记录进行统计分析。结果:证实MPE的患者组(n=67)中,32例为男性(48%),35例为女性(52%)。平均年龄62.3岁(男性65.4岁,女性59.4岁)。三种最常见的原发性恶性肿瘤是肺癌癌症(n=24)、癌症(n=14)和肾脏癌症(n=6)。在38名MPE患者中,通过VATS进行了滑石胸膜固定术,中位生存期为341天(95%CI 256–859)。10名患者在滑石浆胸膜固定术后进行引流,中位生存期为91.5天(95%CI 64-NA)。仅对10例MPE患者进行了引流。所有类型的手术干预后的总中位生存时间为301天(95%CI 207-389天)。结论:MPE的处理取决于患者的预后。对于长期存活的患者,需要进行明确的干预,而对于预期寿命较短的患者,则首选能缩短住院时间的手术。胸腔镜胸膜固定术是一种有效的治疗有症状的MPE患者的方法,具有良好的表现状态、胸膜引流后肺部再次扩张或预期生存率。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
A Retrospective Analysis of the Palliative Surgical Treatment in Patients with Malignant Pleural Effusion
Abstract Introduction: The formation of malignant pleural effusion (MPE) is a clinical manifestation of an advanced malignancy or its dissemination. The focus of treatment is primarily palliative and aimed at relieving symptoms, especially dyspnoea. Material and Methods: Clinical data from patients who were hospitalized at the Clinic of Thoracic Surgery, JFMED CU and Martin University Hospital, in the years 2015–2019 were retrospectively explored and statistically analyzed based on their medical records. Results: From the group of patients with proven MPE (n=67), 32 patients were male (48%) and 35 were female (52%). The mean age was 62.3 years (65.4 for males and 59.4 for females). The three most common primary malignancies were lung cancer (n=24), breast cancer (n=14), and kidney cancer (n=6). In 38 patients with MPE a talc pleurodesis via VATS was performed, with a median survival of 341 days (95% CI 256–859). Drainage following the talc slurry pleurodesis was performed in 10 patients with a median survival of 91.5 days (95% CI 64-NA). Ten patients with MPE underwent drainage only. The overall median survival time after all types of surgical interventions was 301 days (95% CI 207-389 days). Conclusion: Management of MPE depends on the patient´s prognosis. A definitive intervention is required in patients with a long-term survival, while in patients with a short life expectancy procedures leading to the shortest hospital stay are preferred. Videothoracoscopic procedures with pleurodesis represent an effective treatment for patients with symptomatic MPE with a good performance status, presence of lung re-expansion following pleural drainage or expected survival.
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来源期刊
自引率
0.00%
发文量
11
审稿时长
14 weeks
期刊介绍: Acta Medica Martiniana is a medical scientific journal, first published in print form in December 2001. It is a continuation of the journal / almanac Folia Medica Martiniana (1971 - 1996). The journal‘s owner is the Jessenius Faculty of Medicine, Comenius University, Slovakia. Dissemination of research results and scientific knowledge from all areas of medicine and nursing. Stimulation, facilitation and supporting of publication activity for the young medical research and clinical generation. The contributions of young novice authors (PhD students and post-doctorials) are particularly welcome. Acta Medica Martiniana is an open-access journal, with a periodicity of publishing three times per year (Apr/Aug/Dec). It covers a wide range of basic medical disciplines, such as anatomy, histology, biochemistry, human physiology, pharmacology, etc., as well as all clinical areas incl. preventive medicine, public health and nursing. Interdisciplinary and multidisciplinary manuscripts, including papers from all areas of biomedical research, are welcome.
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