尿囊素-十八烯二酸二元体系的共晶形成与皮肤伤口愈合

Karbala International Journal of Modern Science Pub Date : 2023-06-27 DOI:10.33640/2405-609x.3302

S. W. Shah, F. Ali, I. Bibi, Kashif Ali, Neelam Pervaiz, Mariyum Yousaf

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引用次数: 1

摘要

摘要研究了尿囊素-十八烯二酸体系(AOM)中共晶的形成。二元相图显示在X尿囊素= 0.7处存在共晶。通过XRD和SEM分析可知，二乙酸会破坏尿囊素的网状结构，导致缺陷，最终导致结晶度降低。混合后尿囊素热稳定性在TGA图上的变化可以忽略不计。使用Avogadro和BIOVIA Discovery Studio软件预测了经典氢键和烷基相互作用。通过深入的FT-IR光谱研究了系统中相互作用所涉及的功能。该共晶剂对家兔皮肤创面愈合有明显的促进作用，可作为调节和控制其生物活性的药物。

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Eutectic Formation and Cutaneous Wound Healing by Binary Allantoin- Octadecenedioic Acid System

Abstract Eutectic formation in allantoin-octadecenedioic acid system (AOM) has been studied. The binary phase diagram revealed the existence of eutectic at X allantoin = 0.7. Dioic acid caused disruption of network in allantoin and induced defects, ultimately causing the reduction in crystallinity as shown by XRD and SEM analysis. The thermal stability in TGA graphs of allantoin was negligibly altered after mixture formation. Classical hydrogen bonding and alkyl interactions were predicted using software Avogadro and BIOVIA Discovery Studio. The functionalities involved in interactions taking place in the system were studied through in-depth FT-IR spectroscopy. The eutectic showed efficacy for cutaneous wound healing in oryctolagus cuniculus domesticus, hence it could be used as therapeutic for regulation and control of bioactivity.

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来源期刊

Karbala International Journal of Modern Science Multidisciplinary-Multidisciplinary

CiteScore

2.50

自引率

0.00%

发文量