Gd3+/GO/海藻酸盐纳米复合材料MRI纵向弛豫率与钆浓度的相关性

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
Ensiyeh Shafaei, B. Divband, N. Gharehaghaji
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引用次数: 1

摘要

目的:磁共振成像(MRI)弛豫率与磁性纳米颗粒浓度之间的相关性决定了纳米材料提供MRI对比的能力。本研究将海藻酸盐与钆/氧化石墨烯纳米复合材料偶联,形成钆/氧化石墨烯/海藻酸盐纳米复合材料,旨在研究其对MRI纵向弛豫速率与顺磁钆浓度相关性的影响。材料与方法:研究了纳米复合材料的理化性质及其对细胞培养的影响。根据相应的指数曲线确定MRI纵向弛豫率,并绘制其与钆浓度的相关性图。结果:纳米复合材料的平均厚度为3纳米,薄片尺寸为100纳米。即使在相对较高的浓度(75µg/ml)下,纳米复合材料也显示出较高的细胞活力。此外,纵向弛豫速率与钆浓度呈线性相关。结论:钆/氧化石墨烯/海藻酸盐纳米复合材料与钆浓度呈高斜率线性关系,证实了该纳米复合材料具有显著提高MR图像正对比度的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Relevance between MRI longitudinal relaxation rate and gadolinium concentration in Gd3+/GO/alginate nanocomposite
Objective(s): Relevance between magnetic resonance imaging (MRI) relaxation rate and concentration of magnetic nanoparticles determines the capability of a nanomaterial to provide MRI contrast. In the present study, alginate was conjugated to gadolinium/graphene oxide nanocomposite to form gadolinium/graphene oxide/alginate nanocomposite, aiming to investigate its effect on the relevance between MRI longitudinal relaxation rate and paramagnetic gadolinium concentration.Materials and Methods: The physicochemical properties of the nanocomposite and its effect on the cell culture were investigated. Moreover, MRI longitudinal relaxation rates were determined based on the corresponding exponential curves, and the graph of their relevance with gadolinium concentration was plotted. Results: The average thickness and sheet size of the nanocomposite were three and 100 nanometers, respectively. The nanocomposite showed high cell viability, even at the relatively high concentration of 75 µg/ml. In addition, a linear correlation was observed between longitudinal relaxation rate and gadolinium concentration. Conclusion: According to the results, the linearity between gadolinium/graphene oxide/alginate nanocomposite and gadolinium concentration, which revealed a high slope, confirmed the potential of the nanocomposite to significantly improve the positive contrast of MR images.
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
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12 weeks
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