亚洲藤叶对疼痛和炎症动物模型的改善作用

IF 1.2 Q4 PHARMACOLOGY & PHARMACY

Journal of Herbs, Spices and Medicinal Plants Pub Date : 2022-06-20 DOI:10.1080/10496475.2022.2089429

Atamjit Singh, Harpreet Kaur, Hasandeep Singh, Balbir Singh, P. Bedi, Sarabjit Kaur

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引用次数: 1

摘要

摘要在动物模型中评价了积雪草叶溶剂提取物的镇痛和抗炎作用。从叶子中制备的甲醇和乙酸乙酯组分分别在400 mg kg−1和100 mg kg−1。用柱色谱法从乙酸乙酯馏分中分离得到杨梅素。与杨梅素的分子对接研究表明，杨梅素与COX-1和COX-2都有理想的结合模式，支持其抗炎潜力。结果表明，积雪草甲醇提取物的抗炎镇痛作用可能与杨梅素对COX-1和COX-2的抑制作用有关。

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Ameliorative Effects of Grewia asiatica Leaves in Animal Models of Pain and Inflammation

ABSTRACT The analgesic and anti-inflammatory effects of Grewia asiatica leaf solvent extracts were evaluated in animal models. The methanol and ethyl acetate fractions prepared from the leaves showed potent analgesic and anti-inflammatory effects at 400 mg kg−1 and 100 mg kg−1, respectively. Myricetin was isolated from the ethyl acetate fraction by column chromatography. Molecular docking studies with myricetin showed a desirable binding pattern of myricetin with both COX-1 and COX-2, supporting its anti-inflammatory potential. Results showed that the anti-inflammatory and analgesic effect of methanol extract of G. asiatica leaves may be due to COX-1 and COX-2 inhibition by myricetin.

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来源期刊

Journal of Herbs, Spices and Medicinal Plants Medicine-Complementary and Alternative Medicine

CiteScore

3.00

自引率

0.00%

发文量

期刊介绍： The Journal of Herbs, Spices & Medicinal Plants is an essential reference filled with recent research and other valuable information associated with herbs, spices, and medicinal plants. The Journal serves as a focus point through which investigators and others may publish material of importance to the production, marketing, and utilization of these plants and associated extracts. The journal covers the following topics: growth, development, horticulture, ecology, physiology, genetics, chemistry, and economics. Original articles, review articles, and book reviews provide information of interest to an international audience of researchers, teachers, technicians, and managers involved with production and/or marketing of herbs, spices, and medicinal plants. Managers of food companies, food processing facilities, medical research laboratories, government agencies, and others interested in new chemicals, food additives, international trade, patents, and other items can easily review new findings. The Journal of Herbs, Spices & Medicinal Plants is a forum in which recent research and other information associated with herbs, spices, and medicinal plants is shared. The Journal represents a centralized database accessible by investigators within the international community that work with or have an interest in herbs, spices, and medicinal plants.