蜕皮提取物对链脲佐菌素诱导糖尿病大鼠肝脏和胰腺的抗氧化和抗糖尿病作用

Q3 Biochemistry, Genetics and Molecular Biology

Journal of Applied Biotechnology Reports Pub Date : 2021-03-01 DOI:10.30491/JABR.2020.222547.1194

A. R. Ghara, Fereshteh Ezzati Ghadi, Seyed Hamzeh Hosseini, S. Piacente, A. Cerulli, A. Alizadeh, R. Mirmahmoudi

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引用次数: 5

摘要

简介：传统上，山柑的枝条被用作抗糖尿病药物，但其药用价值尚未得到科学证明。本研究评价蜕皮水提取物对链脲佐菌素（STZ）诱导的糖尿病大鼠肝脏和胰腺的抗糖尿病作用和抗氧化活性。材料与方法：采用生化、组织学和红外光谱等方法对山柑蜕膜的药效进行评价。所有的生物化学和生物物理参数都是在每天口服水提取物15天后估计的。结果：结果显示，与对照大鼠相比，口服Capparis蜕膜提取物（250mg/kg）可显著降低糖尿病大鼠的空腹血糖水平。此外，在STZ诱导的糖尿病大鼠中，接受Capparis蜕膜提取物后，脂质过氧化、抗氧化剂、脂质图谱、肝酶水平的改变以及结构变化都得到了逆转。结论：蜕皮水提物具有较强的抗糖尿病和抗氧化活性。

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Antioxidant and Antidiabetic Effect of Capparis decidua Edgew (Forssk.) Extract on Liver and Pancreas of Streptozotocin-Induced Diabetic Rats

Introduction: The twig of Capparis decidua has been traditionally used as an antidiabetic agent but its medicinal use has not been scientifically proved yet. Present study evaluated the antidiabetic effect and antioxidant activities of aquatic extract of twigof Capparis decidua on liver and pancreas of diabetic rats induced by Streptozotocin (STZ). Materials and Methods: The effect of Capparis decidua was evaluated by biochemical, histological and FTIR studies. All biochemical and biophysical parameters were estimated after 15 days of daily oral administrations of the aqueous extract. Results: Results showed that oral use of Capparis decidua extract (250 mg/kg) caused significant reduction in the fasting blood glucose levels in diabetic rats when compared to control rats. Moreover, the altered level of lipid peroxidation, antioxidant, lipid profiles, liver enzymes, and also structural changes were reversed in STZ-induced diabetic rats which received Capparis decidua extract. Conclusions: In conclusion, aqueous extract of Capparis decidua has potent antidiabetic and antioxidant activity.

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来源期刊

Journal of Applied Biotechnology Reports Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

1.90

自引率

0.00%

发文量

期刊介绍： The Journal of Applied Biotechnology Reports (JABR) publishes papers describing experimental work relating to all fundamental issues of biotechnology including: Cell Biology, Genetics, Microbiology, Immunology, Molecular Biology, Biochemistry, Embryology, Immunogenetics, Cell and Tissue Culture, Molecular Ecology, Genetic Engineering and Biological Engineering, Bioremediation and Biodegradation, Bioinformatics, Biotechnology Regulations, Pharmacogenomics, Gene Therapy, Plant, Animal, Microbial and Environmental Biotechnology, Nanobiotechnology, Medical Biotechnology, Biosafety, Biosecurity, Bioenergy, Biomass, Biomaterials and Biobased Chemicals and Enzymes. Journal of Applied Biotechnology Reports promotes a special emphasis on: -Improvement methods in biotechnology -Optimization process for high production in fermentor systems -Protein and enzyme engineering -Antibody engineering and monoclonal antibody -Molecular farming -Bioremediation -Immobilizing methods -biocatalysis