{"title":"ESAT-6：一场完美的战争还是装甲的薄弱环节","authors":"Sachin K. Samuchiwal","doi":"10.15406/MOJI.2017.05.00147","DOIUrl":null,"url":null,"abstract":"Submit Manuscript | http://medcraveonline.com responsible for the substandard efficacy of BCG [2]. Considerable efforts are being made to generate recombinant BCG (rBCG) but with little headway. Causative agent of TB Mycobacterium tuberculosis (M.tb) is remarkably skillful in eluding host defense and modulating immune response for its own benefits. An interesting approach for combating TB is to target M.tb virulence factors [3]. One such key protein is ESAT-6, encoded by region of difference 1 (RD1), the region absent from BCG and most attenuated mycobacterial strains [4,5].","PeriodicalId":90928,"journal":{"name":"MOJ immunology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2017-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ESAT-6: A Perfect Warfare or A Weak Link in Armor\",\"authors\":\"Sachin K. Samuchiwal\",\"doi\":\"10.15406/MOJI.2017.05.00147\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Submit Manuscript | http://medcraveonline.com responsible for the substandard efficacy of BCG [2]. Considerable efforts are being made to generate recombinant BCG (rBCG) but with little headway. Causative agent of TB Mycobacterium tuberculosis (M.tb) is remarkably skillful in eluding host defense and modulating immune response for its own benefits. An interesting approach for combating TB is to target M.tb virulence factors [3]. One such key protein is ESAT-6, encoded by region of difference 1 (RD1), the region absent from BCG and most attenuated mycobacterial strains [4,5].\",\"PeriodicalId\":90928,\"journal\":{\"name\":\"MOJ immunology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2017-01-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"MOJ immunology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.15406/MOJI.2017.05.00147\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"MOJ immunology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.15406/MOJI.2017.05.00147","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Submit Manuscript | http://medcraveonline.com responsible for the substandard efficacy of BCG [2]. Considerable efforts are being made to generate recombinant BCG (rBCG) but with little headway. Causative agent of TB Mycobacterium tuberculosis (M.tb) is remarkably skillful in eluding host defense and modulating immune response for its own benefits. An interesting approach for combating TB is to target M.tb virulence factors [3]. One such key protein is ESAT-6, encoded by region of difference 1 (RD1), the region absent from BCG and most attenuated mycobacterial strains [4,5].
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