铁代谢：稳态中的途径和蛋白质

IF 4.1 3区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Reviews in Inorganic Chemistry Pub Date : 2022-10-24 DOI:10.1515/revic-2022-0031

E. Arora, Vibha Sharma

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引用次数: 0

摘要

铁对人类生存至关重要。这种微量必需无机元素也是一种潜在的毒素，其生物学作用和贩运作用正在不断研究和展开。对氧运输、DNA合成、电子运输、神经递质生物合成至关重要，并且存在于许多其他血红素和非血红素酶中，其生理作用是巨大的。了解在系统和细胞水平上调节这种基本元素的分子和途径对于改善铁相关疾病的治疗策略至关重要。这篇综述强调了在理解铁的代谢和运输以及铁相关疾病的病理生理学方面的进展。

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Iron metabolism: pathways and proteins in homeostasis

Abstract Iron is essential to human survival. The biological role and trafficking of this trace essential inorganic element which is also a potential toxin is constantly being researched and unfolded. Vital for oxygen transport, DNA synthesis, electron transport, neurotransmitter biosynthesis and present in numerous other heme and non-heme enzymes the physiological roles are immense. Understanding the molecules and pathways that regulate this essential element at systemic and cellular levels are of importance in improving therapeutic strategies for iron related disorders. This review highlights the progress in understanding the metabolism and trafficking of iron along with the pathophysiology of iron related disorders.

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来源期刊

Reviews in Inorganic Chemistry 化学-分析化学

CiteScore

7.30

自引率

4.90%

发文量

审稿时长

1 months

期刊介绍： Reviews in Inorganic Chemistry (REVIC) is a quarterly, peer-reviewed journal that focuses on developments in inorganic chemistry. Technical reviews offer detailed synthesis protocols, reviews of methodology and descriptions of apparatus. Topics are treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are committed to high quality standards and rapid handling of the review and publication process. The journal publishes all aspects of solid-state, molecular and surface chemistry. Topics may be treated from a synthetic, theoretical, or analytical perspective. The editors and the publisher are commited to high quality standards and rapid handling of the review and publication process. Topics: -Main group chemistry- Transition metal chemistry- Coordination chemistry- Organometallic chemistry- Catalysis- Bioinorganic chemistry- Supramolecular chemistry- Ionic liquids